Decapeptide-20 is a synthetic peptide known under the trade name CG-Promkine that interacts with receptors for the melanocyte-stimulating hormone preventing the loss of pigment by hair keratinocytes.
Peptides
There are numerous examples in physiology of peptide regulatory elements that play integral roles in basic homeostatic mechanisms such as injury-repair responses and other stimulus-response actions. Among these are well-known neuropeptides (e.g., bradykinins, endorphins); metabolism and fat storage regulators (e.g., neuropeptide Y, leptin, insulin); tanning and skin pigmentation-related peptides (e.g., α-MSH, ACTH, Agouti), and peptides involved in wound healing (e.g., FGF).
This large group of innovative cosmeceutical ingredients triumphed in the world of skincare products during the last two decades. Peptides are chains of amino acids that are attached in a specific order. Amino acids are naturally occurring in the body and are vital to everyday living processes. Peptides can be made up of 2 or more amino acids that can stimulate different responses within the body. As a result, peptides serve as tiny messengers that can be sent to kick the skin into gear and make it look better.
Peptides are leading a beauty revolution due to their excellent multi-functional properties; formularies are scrambling to access the latest advances in cosmetic peptide technology. In addition, their "Botox-like" performance, activation of collagen and elastin production, and skin-lightening effect make them very efficient against coarse wrinkles and hyperpigmentation of the skin.
Decapeptide-4 is a synthetic peptide known under the trade name CG-IDP2 that mimics the Somatomedin growth factor involved in normal skin growth, healing, and wound repair. Applied topical, it boosts collagen and elastin production improving skin elasticity and firmness.
Delisens™ is a peptide-based complex ingredient widely used in personal care products with soothing, anti-inflammatory, anti-allergic, and hydrating effects.
It is well known that skin pigmentation is mainly affected by three major signaling pathways; α-MSH/MC-1R, ET-1/ETBR, and SCF/c-kit.
Collagen represents the main component of the extracellular matrix of the dermal connective tissue and its concentration decreases as we age. It is known that the loss of collagen is not only due to a reduction of the synthesis but also due to its enhanced degradation.
Ceramide 2 replenishes the lipid barrier and improves the skin's water-binding ability, smoothing fine lines and deep wrinkles. Palmitoyl Hexapeptide-12 stimulates fibroblasts' mobility and boosts elastin production, improving skin elasticity and firmness.
Detoxiquin is a peptide-based complex ingredient that unites Snow mushroom extract with an iron-containing synthetic peptide to protect DNA from reactive radicals, reduce lipid peroxidation, and decrease protein degeneration.
Skin aging is a progressive accumulation of damage, beginning at the molecular level within the dermal cells. Transition metals are one of the factors responsible for the formation of highly reactive and DNA-damaging species (free radicals).
Diamond Sirt is a conjugated complex formed by silicon dioxide microspheres covered with aggregated diamonds that stabilize function-sirtuin peptide (Acetyl sh-Pentapeptide-35) for use in anti-aging treatments.
Dipeptide-2 is a biologically active peptide with the sequence Val-Trp (VW) that can inhibit both Angiotensin Converting Enzymes
Dipeptide-8 (Alanyl-hydroxyproline; Ala-Hyp) is a synthetic peptide initially found in hydrolyzed collagen mixture.
ECM-Protect® is a peptide that inhibits the enzymatic activity of the elastase and the cutaneous MMP-1. ECM-Protect® defends the body’s collagen and elastin network against harmful damage caused by environmental factors (UV radiation, pollution, cigarette smoke) and aging.
Elaidoyl Tripeptide-37 is a synthetic lipo-peptide with sequence Elaidyl-KFK (Elaidyl-Lys-Phe-Lys-OH) known under the trade name Lipospondin. It is an ester of elaidic acid and Tripeptide-37 (KFK peptide), which repeats a part of the sequence of Thrombospondin.
As the skin is stressed during the aging process, the synthetic activity of cells decreases in general. The production of MFAP-4 is reduced and the whole process of elastin fiber formation is negatively involved from its first stage.
Eyeliss™ is a peptide complex consisting of three biologically active ingredients: Hesperidin methyl chalcone, Dipeptide-2 (Valyl-Tryptophane; Dipeptide-VW), a lipopeptide Palmitoyl Tetrapeptide-7 (Pal-GQPR) that prevents puffiness and diminishes under-eye bags.
Fluorenylmethyloxycarbonyl Glutamoyl Dipeptide-55 Gamma Tetrapeptide-58 is a synthetic peptide known under the trade name Phytoheptapeptide with antioxidant, skin whitening, and wrinkle improvement effects.
Glutamoyl Cysteinoyl Beta-Alaninoyl Glutamoyl Tetrapeptide-58 is a synthetic peptide manufactured through the chemical synthesis of soybean peptides. It is known under the Catchitide-2 and is designed for antioxidant, whitening, and wrinkle improvement action.
Glutamoyl Dipeptide-55 Gamma Tetrapeptide-58 is a synthetic peptide using one of the small peptide sequences of proteins in soybeans. Manufacturer claims an antioxidant, skin whitening, and wrinkle improvement action. It is known under the trade name Catchitide-1.
Golden Collagenine combines gold and platinum with the efficacy of peptides to dramatically reduce wrinkles.
Haloxyl™ is a peptide complex based on four biologically active molecules, including matrikine lipopeptides Palmitoyl Tripeptide-1 (Pal-GHK) and Palmitoyl Tetrapeptide-7 (Pal-GQPR), iron chelating N-hydroxysuccinimide (NHS), and a flavonoid chrysin, that eliminates under-eye bags and dark circles.
Heptapeptide-15 mimics skin’s natural growth factors, stimulating fibroblasts differentiation and proliferation and enhancing extracellular matrix components production, such as collagen, elastin, and GAGs.
Heptapeptide-28 is a synthetic peptide that promotes hair growth inducing follicle cell proliferation and differentiation. This peptide is also known under the trade name CG-Alostop.
Turmeric (Curcuma longa) is a spice used in oriental cuisine and medicine (traditional Chinese and Ayurveda) and as an ingredient in beauty preparations. It contains Turmerin protein with antioxidant and anti-inflammatory properties.
Heptapeptide-7 is a synthetic peptide with sequence Met-Gly-Arg-Asn-Ile-Arg-Asn, a fragment of a well-studied peptide HB-107 with wound-healing and anti-aging properties.
Heptapeptide-8 is a synthetic bioactive peptide that repeats a part of Laminin-5 and mimics its stimulating action. It boosts the production of Laminin-5 and Beta-1 integrin proteins improving DEJ (dermal-epidermal junction) and entire skin integrity.
Hexanoyl Dipeptide-3 Norleucine Acetate is a synthetic biomimetic tripeptide that boosts the natural desquamation process of the skin. It occupies the binding site of a protein (desmosome) responsible for epidermal cell adherence, acting as a "smart" exfoliating agent.
Hexapeptide-2 is a synthetic peptide with sequence His-Trp-Ala-Trp-Phe-Lys, a competitor (antagonist) of endogenous α-MSH (peptide; alpha-Melanocyte-stimulating hormone) that promotes melanin pigment production and skin pigmentation.
Hexapeptide-3 is a synthetic biomimetic peptide (with the sequence: Ala-Asp-Leu-Lys-Pro-Thr) that mimics fibronectin found in skin extracellular matrix (ECM) and is involved in tissue repair, wound healing, and cell adhesion.
Hexapeptide-33 is a biologically active peptide that stimulates blood vessel formation, known under the trade name W3 peptide. It was developed by Novacell Technology (NCP901) using peptide library technology.