Acetyl Hexapeptide-51 Amide

An organism's ability to repair DNA damage is correlated with its longevity. The DNA repair process is a very important capacity that induces cell survival and, at the same time, the need to activate solutions that avoid errors in its replication.

Acetyl Hexapeptide-51 Amide is a synthetic peptide that mimics the action of FOXO3a, a transcription factor that regulates the response to genetic damage, stimulating natural mechanisms to avoid errors in DNA replication, maintaining integrity, and delaying signs of skin aging. This hexapeptide is considered the true guardian of genomic integrity for the skin cells.

Acetyl Hexapeptide-51 Amide is known under the trade name Juveleven™ and is an ideal ingredient for skin care formulations providing longevity and cellular vitality, and protecting genomic integrity caused by various factors such as exposure to UV rays, stress, DNA replication, and diet. It got a silver medal as an innovative ingredient at In-Cosmetics 2013 in Bangkok.

A study was conducted to evaluate the effectiveness of Acetyl Hexapeptide-51 Amide in repairing genetic damage induced by UV radiation. Skin exposed to irradiation undergoes numerous changes in DNA (red nuclei) compared to non-irradiated skin, as shown in the human epidermal cell biopsy below. Results showed that Acetyl Hexapeptide-51 Amide decreases genetic damage induced by UV radiation in the nuclei of human epidermal cells by 13.7% after 6 hours.

Another study was carried out to determine the photo-protective effect of Acetyl Hexapeptide-51 Amide in the presence of a cytotoxic dose of simulated sunlight on human dermal fibroblasts (HDFA). It showed a significant protective effect, increasing the cell viability of HDFA exposed to irradiation by 35.1% versus untreated irradiated cells.

Functions
Anti-aging
Protective
Skin conditioning
Synonyms
Juveleven™
F.A.Q.

What are the benefits and advantages of Acetyl Hexapeptide-51 Amide?

  • Shields genomic integrity, activating the natural DNA repair process
  • Mimics the activity of FOXO3a, reversing cellular aging
  • Preserves the skin's vital code
  • Reduces DNA damage, caused by UV radiation
  • Protects cells against pollutants and other environmental damaging factors
  • Reverses cellular senescence in the last 11 years

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