Acetyl Hexapeptide-51 Amide

An organism's ability to repair DNA damage is correlated with its longevity. The DNA repair process is a very important capacity that induces cell survival and, at the same time, the need to activate solutions that avoid errors in its replication.

Acetyl Hexapeptide-51 Amide is a synthetic peptide that mimics the action of FOXO3a, a transcription factor that regulates the response to genetic damage, stimulating natural mechanisms to avoid errors in DNA replication, maintaining integrity, and delaying signs of skin aging. This hexapeptide is considered the true guardian of genomic integrity for the skin cells.

Acetyl Hexapeptide-51 Amide is known under the trade name Juveleven™ and is an ideal ingredient for skin care formulations providing longevity and cellular vitality, and protecting genomic integrity caused by various factors such as exposure to UV rays, stress, DNA replication, and diet. It got a silver medal as an innovative ingredient at In-Cosmetics 2013 in Bangkok.

A study was conducted to evaluate the effectiveness of Acetyl Hexapeptide-51 Amide in repairing genetic damage induced by UV radiation. Skin exposed to irradiation undergoes numerous changes in DNA (red nuclei) compared to non-irradiated skin, as shown in the human epidermal cell biopsy below. Results showed that Acetyl Hexapeptide-51 Amide decreases genetic damage induced by UV radiation in the nuclei of human epidermal cells by 13.7% after 6 hours.

Another study was carried out to determine the photo-protective effect of Acetyl Hexapeptide-51 Amide in the presence of a cytotoxic dose of simulated sunlight on human dermal fibroblasts (HDFA). It showed a significant protective effect, increasing the cell viability of HDFA exposed to irradiation by 35.1% versus untreated irradiated cells.

Functions
Anti-aging
Protective
Skin conditioning
Synonyms
Juveleven™
F.A.Q.

What are the benefits and advantages of Acetyl Hexapeptide-51 Amide?

  • Shields genomic integrity, activating the natural DNA repair process
  • Mimics the activity of FOXO3a, reversing cellular aging
  • Preserves the skin's vital code
  • Reduces DNA damage, caused by UV radiation
  • Protects cells against pollutants and other environmental damaging factors
  • Reverses cellular senescence in the last 11 years

Related ingredients

1,2-Hexanediol
1,2-Hexanediol
1,2-Hexanediol is glycol alcohol (with two hydroxy groups on 1 and 2 positions and six carbon atoms), a multifunctional ingredient used as a solvent, emollient, moisturizing agent, and preservative in skin and hair care applications.
Abyssinian Oil
Abyssinian Oil
Abyssinian oil (Crambe oil) achieves a significant improvement on the surface structure as well as the evenness of the skin tone.
Acetyl Dipeptide-1 Cetyl ester
Acetyl Dipeptide-1 Cetyl ester
This lipopeptide exhibits good stimulating results on elastin production. As a result, Acetyl Dipeptide-1 Cetyl ester fights against cutaneous sagging and decreases the visible effects of gravity on the skin.
Acetyl Heptapeptide-9
Acetyl Heptapeptide-9 mimics the TGFβ. Acetyl Heptapeptide-9 effects on fibroblasts, stimulating collagen, elastin, and other components of ECM production.
Acetyl octapeptide-3
Acetyl octapeptide-3
Acetyl Octapeptide-3 is a brilliant, new, deep penetrating, powerful amino-peptide with a fantastic ‘BOTOX® like’ effect.
Acmella Oleracea Extract
Acmella Oleracea Extract
Acmella Oleracea is an exotic plant, also known as Paracress. In the Indian Ocean region, it is called "Mafane". Reduces facial muscle micro-contractions, smoothes and reduces lines and wrinkles.
Acnacidol™ BG
Acnacidol™ BG
Acnacidol™ BG is a clinically tested complex that contains Queen bee acid (10-HDA or 10-Hydroxydecanoic Acid found in Royal Jelly that controls and reduces sebum and the appearance of acne.
Adenosine 5 Triphosphate (ATP)
Adenosine 5 Triphosphate (ATP)
Naturally existing in our bodies as part of the molecule adenosine triphosphate (ATP), responsible for transporting energy for numerous cellular and muscular functions in our body
Alanine
Alanine
Alanine is an amino acid permanently produced in the human body. It is included in beauty formulations as an effective skin humectant.
Alaria esculenta extract
Alaria esculenta extract
Rich in antioxidant oligosaccharides protects the skin from UV-induced damage and oxidative stress. Alaria esculenta extract has a skin-lightening effect similar to vitamin B3.
Algae Extract
Algae Extract
Contains micro-nutrients such as iron, manganese, zinc, magnesium, copper.
Alistin®
Alistin®
Alistin® (Decarboxy Carnosine) is a synthetic antiaging pseudodipeptide with high stability and resistance to enzymatic hydrolysis, that cell membranes oxidative stress and dermal fiber from cross-linking.