Acetyl Tetrapeptide-40

Functions
Anti-inflammatory
Protective
Soothing
Skin conditioning
CAS Number(s)
1472633-28-5

Acetyl Tetrapeptide-40 is a synthetic peptide that decreases the realize of pro-inflammatory interleukins (IL-6 and IL-8) fighting against skin redness, erythema, and telangiectasias. It is known under the trade name Telangyn™ and the sequence is Acetyl-Ala-Thr-Asn-Thr.

Cathelicidins are antimicrobial peptides that protect the skin from infections. LL-37 is a 37-amino-acid-long peptide, a human cathelicidin. Its overexpression increases pro-inflammatory interleukin production resulting in an excessive inflammatory response appearing as erythema, irritation, or similar skin conditions.

Acetyl Tetrapeptide-40 interleukins realize and normalize the skin's inflammatory response, reducing post-inflammatory hyperpigmentation, dilated capillaries appearance, and erythema. Limiting excessive immune response, it also prevents Matrix metalloproteinase (MMP) activation responsible for the skin's structural proteins (mainly collagen) destruction preserving skin elasticity, firmness, and resilience.

In addition, Acetyl Tetrapeptide-40 modulates UV-induced skin inflammation and exhibits photoprotective properties, reducing dermal cell damage and other negative effects. It is a safe and effective ingredient, used in minimal concentrations of 0.05% for after-sun, soothing, and anti-aging applications.
Synonyms
Telangyn™

Related ingredients

1,2-Hexanediol
1,2-Hexanediol
1,2-Hexanediol is glycol alcohol (with two hydroxy groups on 1 and 2 positions and six carbon atoms), a multifunctional ingredient used as a solvent, emollient, moisturizing agent, and preservative in skin and hair care applications.
Abyssinian Oil
Abyssinian Oil
Abyssinian oil (Crambe oil) achieves a significant improvement on the surface structure as well as the evenness of the skin tone.
Acetyl Dipeptide-1 Cetyl ester
Acetyl Dipeptide-1 Cetyl ester
This lipopeptide exhibits good stimulating results on elastin production. As a result, Acetyl Dipeptide-1 Cetyl ester fights against cutaneous sagging and decreases the visible effects of gravity on the skin.
Acetyl Heptapeptide-9
Acetyl Heptapeptide-9 mimics the TGFβ. Acetyl Heptapeptide-9 effects on fibroblasts, stimulating collagen, elastin, and other components of ECM production.
Acmella Oleracea Extract
Acmella Oleracea Extract
Acmella Oleracea is an exotic plant, also known as Paracress. In the Indian Ocean region, it is called "Mafane". Reduces facial muscle micro-contractions, smoothes and reduces lines and wrinkles.
Acnacidol™ BG
Acnacidol™ BG
Acnacidol™ BG is a clinically tested complex that contains Queen bee acid (10-HDA or 10-Hydroxydecanoic Acid found in Royal Jelly that controls and reduces sebum and the appearance of acne.
Adenosine 5 Triphosphate (ATP)
Adenosine 5 Triphosphate (ATP)
Naturally existing in our bodies as part of the molecule adenosine triphosphate (ATP), responsible for transporting energy for numerous cellular and muscular functions in our body
Alanine
Alanine
Alanine is an amino acid permanently produced in the human body. It is included in beauty formulations as an effective skin humectant.
Alaria esculenta extract
Alaria esculenta extract
Rich in antioxidant oligosaccharides protects the skin from UV-induced damage and oxidative stress. Alaria esculenta extract has a skin-lightening effect similar to vitamin B3.
Algae Extract
Algae Extract
Contains micro-nutrients such as iron, manganese, zinc, magnesium, copper.
Alistin®
Alistin®
Alistin® (Decarboxy Carnosine) is a synthetic antiaging pseudodipeptide with high stability and resistance to enzymatic hydrolysis, that cell membranes oxidative stress and dermal fiber from cross-linking.
Alpha-Glucan Oligosaccharide
Alpha-Glucan Oligosaccharide
Thanks to the specificity of its inter-glycosidic bonds, Alpha-Glucan is a selective substrate for the nutrition and development of the skin's saprophytic (beneficial) flora to the detriment of undesirable opportunists flora (pathogenic or not) ready to invade the skin at the slightest sign of imbalance.