Tetrapeptide-26

Functions
Protective
Photoprotective
Anti-aging
Skin conditioning
FDA UNII
5BF6JG6X25

Our skin has an essential regulatory function, which activity depends on the circadian rhythm. It activates cellular defense processes in the skin during daylight and deactivates during night.

Tetrapeptide-26 is a synthetic peptide with the sequence Ser-Pro-Leu-Gln-NH2, known under the trade name Chronogen®, that activates genes CLOCK (Circadian Locomotor Output Cycles Kaput), BMAL1 (Basic Helix-Loop-Helix ARNT Like 1), and PER1 (Period Homolog 1) in keratinocytes, which encode proteins responsible for the regulation of cellular defense mechanisms with circadian rhythms.

Similarly to Tripeptide-32 (Chronolux®), Tetrapeptide-26 also activates genes that promote natural defenses against UV and other environmental factors damage during the day on a cellular level and increases natural DNA repair processes at night. Compared with Tripeptide-32, it also enhances the expression of BMAL1, which forms a heterodimer complex with CLOCK, improving the entire efficiency of this active ingredient.

Boosting the production of proteins involved in DNA repair processes, Tetrapeptide-26 allows activation of the skin's natural defense independent of the day/night cycle and simplifies customers' skincare regimens. It noticeably improves the keratinocyte survival rate after exposure of environmental damaging factors, which is especially important for those who live in urban areas. It strengthens the skin barrier function, preserves health, and prevents premature aging.
Synonyms
Chronogen®

Related ingredients

1,2-Hexanediol
1,2-Hexanediol
1,2-Hexanediol is glycol alcohol (with two hydroxy groups on 1 and 2 positions and six carbon atoms), a multifunctional ingredient used as a solvent, emollient, moisturizing agent, and preservative in skin and hair care applications.
Abyssinian Oil
Abyssinian Oil
Abyssinian oil (Crambe oil) achieves a significant improvement on the surface structure as well as the evenness of the skin tone.
Acetyl Dipeptide-1 Cetyl ester
Acetyl Dipeptide-1 Cetyl ester
This lipopeptide exhibits good stimulating results on elastin production. As a result, Acetyl Dipeptide-1 Cetyl ester fights against cutaneous sagging and decreases the visible effects of gravity on the skin.
Acetyl Heptapeptide-9
Acetyl Heptapeptide-9 mimics the TGFβ. Acetyl Heptapeptide-9 effects on fibroblasts, stimulating collagen, elastin, and other components of ECM production.
Acetyl octapeptide-3
Acetyl octapeptide-3
Acetyl Octapeptide-3 is a brilliant, new, deep penetrating, powerful amino-peptide with a fantastic ‘BOTOX® like’ effect.
Acmella Oleracea Extract
Acmella Oleracea Extract
Acmella Oleracea is an exotic plant, also known as Paracress. In the Indian Ocean region, it is called "Mafane". Reduces facial muscle micro-contractions, smoothes and reduces lines and wrinkles.
Acnacidol™ BG
Acnacidol™ BG
Acnacidol™ BG is a clinically tested complex that contains Queen bee acid (10-HDA or 10-Hydroxydecanoic Acid found in Royal Jelly that controls and reduces sebum and the appearance of acne.
Adenosine 5 Triphosphate (ATP)
Adenosine 5 Triphosphate (ATP)
Naturally existing in our bodies as part of the molecule adenosine triphosphate (ATP), responsible for transporting energy for numerous cellular and muscular functions in our body
Alanine
Alanine
Alanine is an amino acid permanently produced in the human body. It is included in beauty formulations as an effective skin humectant.
Alaria esculenta extract
Alaria esculenta extract
Rich in antioxidant oligosaccharides protects the skin from UV-induced damage and oxidative stress. Alaria esculenta extract has a skin-lightening effect similar to vitamin B3.
Algae Extract
Algae Extract
Contains micro-nutrients such as iron, manganese, zinc, magnesium, copper.
Alistin®
Alistin®
Alistin® (Decarboxy Carnosine) is a synthetic antiaging pseudodipeptide with high stability and resistance to enzymatic hydrolysis, that cell membranes oxidative stress and dermal fiber from cross-linking.