Acetyl Hexapeptide-37

Functions
Hydrating
Barrier enhancer
Firming
Smoothing
Skin conditioning
CAS Number(s)
1447824-16-9

Acetyl Hexapeptide-37 (known under the trade name Diffuporine™) is a synthetic peptide found by combinatorial peptide screening technology. Scientists from Lipotec S.A. monitored human keratinocyte cells treated with peptides that can produce luminescence when in contact with the luciferase.

Among several peptides, Acetyl Hexapeptide-37 with sequence (Ac-L-Ser-L-Pro-L-Ala-Gly-Gly-L-Pro-NH2) showed promising results in increasing expression of human AQP3 (Aquaporin-3) gene and boosting its production up to twice. Increased Aquaporin-3 levels enhance water flux from deeper skin layers to the Stratum Corneum, improving skin hydration and keratinocyte protection and viability.

Besides adequate skin hydration, Acetyl Hexapeptide-37 exhibits additional anti-aging effects, including beneficial action on keratinocytes and fibroblasts. It promotes keratinocyte cell proliferation, improving skin barrier function and reducing transdermal moisture loss. In addition, Diffuporine™ increases cell viability after cold, dry, or other extreme conditions.

Applied topically, Acetyl Hexapeptide-37 stimulates dermal fibroblasts and boosts Collagen type 1 production, improving skin smoothness, firmness, and elasticity. It is a multifunctional anti-aging peptide that moisturizes, revives, and rejuvenates the skin, exposing a fresh, healthy, and youthful appearance.
Synonyms
Diffuporine™

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