Acetyl sh-Hexapeptide-5 Amide Acetate

Acetyl sh-Hexapeptide-5 Amide Acetate is a derivative of a synthetic peptide derived from Versican proteoglycan (glycosylated protein). Versican is present in the extracellular matrix (ECM) of many human tissues and organs, including skin, where it performs many functions. It binds and interacts with HA, fibrillin-1, and fibronectin improving water retention, microfibrils connection and organization, and regulating collagen fibrillogenesis and fibril assembly within the fibers.

Acetyl sh-Hexapeptide-5 amide acetate is a bio-mimetic of Versican (sequence corresponds to the N-terminal region of Versican). Preventing elastin degradation (inhibits elastase and production of metalloproteinases 1 and 3), it promotes tropoelastin, hyaluronic acid, and other ECM components production and assembly, improving skins' visco-elasticity in a complex, enhancing volume, elasticity, and flexibility. Acetyl sh-Hexapeptide-5 amide acetate remodels the skin, strengthens cohesion, and improves firmness.

Acetyl sh-Hexapeptide-5 amide acetate promotes the fibrillin-versican-hyaluronic acid complex formation, reinforcing skin ligaments, their anchoring, and moving ligaments into the original position (repositioning). This peptide-based ingredient is safe and suitable for all types of anti-aging formulations.

Functions
Anti-aging
Firming
Hydrating
Remodeling
Smoothing
Skin conditioning
Synonyms
Versillin™

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