Oligopeptide-24 (former Oligopeptide-23; known under the trade name CG-EDP3) is a synthetic biomimetic peptide that stimulates skin cell proliferation by up-regulation of EGF (Epidermal Growth Factor) expression. It mimics a key component in regulating the renewal of all skin structures: epidermal and dermal cells, hyaluronic acid molecules, collagen fibers, elastin, and fibronectin.
Oligopeptide-24 showed upregulation of cell growth and migration, cell survival, extracellular matrix expression, and a certain type of growth factor expression in skin cell lines. It smooths fine lines and wrinkles exposing youthful skin appearance.
A scientific study showed that the EGF concentration was increased in fibroblast cells after 72hr treatment of Oligopeptide-24 in the condition of serum-free culture. In addition, CG-EDP3 showed positive regulation of Hyaluronic acid and fibronectin expression. Increased expression of hyaluronic acid (3 folds) and Elastin (1.3 fold) was observed in dose
dependant manner with Oligopeptide-24 in fibroblast cells.