sh-Nonapeptide-4

sh-Nonapeptide-4 is a synthetic recombinant peptide known under the trade name Clodessine, a fragment of human Klotho protein that activates different Fibroblasts Growth Fatrors (FGF) and is related to lognitivity. Klotho is considered to be an anti-aging factor.

sh-Nonapeptide-4 inhibits Insulin Growth Factor (IGF) receptors referring to premature aging and stimulates the production of Superoxide dismutase and Catalase enzymes, antioxidants that provide a natural defense against reactive species, protecting dermal cells from oxidative stress.

Protecting dermal cells from environmental damaging factors,sh-Nonapeptide-4 also activates DNA repair processes in the skin cells, preventing premature aging, extending cell lifespan, and preserving natural beauty. It improves skin elasticity and visibly reduces wrinkles and pores.

In addition, sh-Nonapeptide-4 increases energy production, enhancing cell metabolism, function, and viability. Incorporated in skin care applications, this peptide effectively fights against fine lines and wrinkles, exposing a smoother, fresher, and more youthful appearance.
Functions
Anti-aging
Smoothing
Firming
Skin conditioning
Synonyms
Clodessine

Related ingredients

1,2-Hexanediol
1,2-Hexanediol
1,2-Hexanediol is glycol alcohol (with two hydroxy groups on 1 and 2 positions and six carbon atoms), a multifunctional ingredient used as a solvent, emollient, moisturizing agent, and preservative in skin and hair care applications.
Abyssinian Oil
Abyssinian Oil
Abyssinian oil (Crambe oil) achieves a significant improvement on the surface structure as well as the evenness of the skin tone.
Acetyl Dipeptide-1 Cetyl ester
Acetyl Dipeptide-1 Cetyl ester
This lipopeptide exhibits good stimulating results on elastin production. As a result, Acetyl Dipeptide-1 Cetyl ester fights against cutaneous sagging and decreases the visible effects of gravity on the skin.
Acetyl Heptapeptide-9
Acetyl Heptapeptide-9 mimics the TGFβ. Acetyl Heptapeptide-9 effects on fibroblasts, stimulating collagen, elastin, and other components of ECM production.
Acetyl octapeptide-3
Acetyl octapeptide-3
Acetyl Octapeptide-3 is a brilliant, new, deep penetrating, powerful amino-peptide with a fantastic ‘BOTOX® like’ effect.
Acetyl Tetrapeptide-5
Acetyl Tetrapeptide-5
Acetyl Tetrapeptide-5 is a fantastic, super effective, naturally derived tetrapeptide that helps reduce the look of puffy eye bags and dark circles under the eyes and helps prevent them from reappearing.
Acmella Oleracea Extract
Acmella Oleracea Extract
Acmella Oleracea is an exotic plant, also known as Paracress. In the Indian Ocean region, it is called "Mafane". Reduces facial muscle micro-contractions, smoothes and reduces lines and wrinkles.
Acnacidol™ BG
Acnacidol™ BG
Acnacidol™ BG is a clinically tested complex that contains Queen bee acid (10-HDA or 10-Hydroxydecanoic Acid found in Royal Jelly that controls and reduces sebum and the appearance of acne.
Adenosine 5 Triphosphate (ATP)
Adenosine 5 Triphosphate (ATP)
Naturally existing in our bodies as part of the molecule adenosine triphosphate (ATP), responsible for transporting energy for numerous cellular and muscular functions in our body
Alanine
Alanine
Alanine is an amino acid permanently produced in the human body. It is included in beauty formulations as an effective skin humectant.
Algae Extract
Algae Extract
Contains micro-nutrients such as iron, manganese, zinc, magnesium, copper.
Alistin®
Alistin®
Alistin® (Decarboxy Carnosine) is a synthetic antiaging pseudodipeptide with high stability and resistance to enzymatic hydrolysis, that cell membranes oxidative stress and dermal fiber from cross-linking.