sh-Polypeptide-121

sh-Polypeptide-121 is a synthetic single-chain recombinant peptide derived from human collagen type 21 (also called collagen alpha-1 and encoded by the COL21A1 gene). It is known under the trade name HumaColl™21.

Structurally, sh-Polypeptide-121 contains amino acid triplets starting with glycine, and the most often occurring triplet (about 10.5%) is a Gly-Pro-Hyp, which is a well-known sequence and individually is a biomimetic peptide (Tripeptide-29) that enhances natural collagen production in the skin, reducing wrinkles reduction, firming, and improving elasticity.

According to the manufacturer's claim, besides wrinkle reduction, sh-Polypeptide-121 also effectively fights against erythema, and improves hydration and skin tone. Stimulating fibroblasts, it boosts collagen, elastin, and hyaluronic acid production.

In addition, sh-Polypeptide-121 improves the skin's tactile and visual texture, exposing a smoother, youthful, and radiant appearance. Incorporated in skincare preparations, it showed excellent skin compatibility, safety, and effectiveness and is used in many high-end anti-aging products.
Functions
Firming
Smoothing
Anti-aging
Hydrating
Film-forming agent
Skin conditioning
Synonyms
HumaColl™21
Human collage type 21
Collagen alpha-1

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