Tetrapeptide-21

Functions
Firming
Anti-aging
Smoothing
Hydrating
Skin conditioning
FDA UNII
179JUC43HU

Tetrapeptide-21 (GEKG-peptide) is a synthetic peptide that repeats a part of a sequence (Gly-Glu-Lys-Gly) of several extracellular matrix (ECM) proteins such as collagens I, II, III, IV, V, elastin, and pro-elastin. It boosts collagen, hyaluronic acid, and fibronectin production by dermal fibroblasts.

It is scientifically proven that fragments of ECM proteins (breakdown product peptides) stimulate regenerative and wound-healing processes in the skin. Tetrapeptide-21 is one of the most effective peptides, which enhances gene expression responsible for collagen production up to  2.5-fold.

In addition, GEKG-peptide increases the expression of genes responsible for the production of other important ECM components, including proteins and glycosaminoglycans (GAGs). Increased hyaluronic acid binds more water molecules, providing adequate hydration, enhanced skin elasticity, and additional volume.

Thanks to the additional production of Fibronectin glycoprotein, Tetrapeptide-21 improves the linking ECM components (such as hyaluronic acid, collagen, and elastin) like a network exposing the skin's firmer, supple, youthful appearance.

Tetrapeptide-21 is a safe and effective anti-aging ingredient. Incorporated in skin care applications, it improves the overall condition and structure of the skin, fights against fine lines and deep wrinkles, and lessens roughness.

Synonyms
TEGO® Pep 4-17

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