White truffle (Tuber Magnatum), a hypogeum fungus known since the mist of time and greatly appreciated for its culinary uses, is the rarest variety of truffles as it grows in some extremely limited areas in Italy. In nature, truffles attract animals using volatile compounds.
To date, more than 200 different molecules have been identified from truffle species and some of these compounds are able to attract animals due to their similarities to some pheromones, this can explain why the white truffle aroma is so appreciated.
To investigate the effect that the white truffle phytocomplex can deliver to the skin in terms of gene expression modulation a microarray analysis was performed on keratinocytes and human fibroblasts. Samples treated with Tuber Magnatum Extract revealed, that several groups of genes were modulated with some interesting down regulations of the metalloproteinases (MMPs) and upregulation of the extracellular matrix (ECM) proteins, aquaporins, vitagenes, and damaged protein degradation process.