Acetyl Tetrapeptide-11

CAS Number(s)

Today older people are still active and comfortable with their life experiences. But one sign of aging is still undesirable: pale skin. Manufacturers of body care products offer numerous anti-aging products that are specially tailored to the needs of mature skin.

Laboratoires Sérobiologiques, the division of Cognis Care Chemicals specializing in cosmetic active ingredients, has therefore developed Acetyl Tetrapeptide-11, an active peptide with sequence Ac-Pro-Pro-Tyr-Leu, that inhibits the effects of skin aging. It specifically targets the epidermis, which thins with age, becomes more fragile, and loses its radiance. Acetyl Tetrapeptide-11 acts on the two components of the epidermis that are mainly responsible for its cohesion, strengthening the skin's structure and giving it a smooth, youthful appearance.

The skin aging process is determined by two molecules:

  1. Syndecan-1 is a small proteoglycan whose production decreases with age, which in turn impairs epidermal cohesion.
  2. Collagen XVII is a protein found in hemidesmosomes - microscopic, punctiform adhesive complexes that influence adhesion between the epidermis and the dermo-epidermal junction.

Acetyl Tetrapeptide-11 improves the skin's elasticity and cohesion, among other things by stimulating the synthesis of Syndecan-1 and Collagen XVII. It reinforces the cohesion of the epidermis and improves the adhesion between the dermis and the dermal-epidermal junction. The result: more elastic, firmer skin with a refined skin texture.

Efficacy proved on a panel of retirees over 65 years of age. Their skin now reflects their inner strength; it expresses their joy in life and their pride: aging, yes, but with beauty and grace. Acetyl Tetrapeptide-11 is suitable for use in anti-aging face creams and care products for mature skin.


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