Elastin, together with collagen, glycosaminoglycans, and other components of the extracellular matrix (ECM), promotes firmness, rigidity, elasticity, and mechanical support for the skin. The correlation of these components must be perfect in order to guarantee the physical properties of the skin.
A variety of environmental, hormonal, and genetic factors result in the loss of skin elasticity and firmness, causing visible manifestations on the face and body. Solar radiation is the main reason for extrinsic aging, as excessive exposure to the sun causes photoaging due to the increase in the action of metalloproteinases and elastases, which consequently accelerates the degradation of collagen and elastin in the dermis.
Acetylarginyltryptophyl Diphenylglycine (known under the trade name Relistase™; with sequence Ac-Arg-Trp-Phg-Phg-OH) is a tetrapeptide that reduces elastase (enzyme) activity by protecting elastin and other components of the extracellular matrix that are susceptible to being degraded by enzymes. Relistase™ also increases collagen synthesis which promotes support and restores skin integrity.
Restoring skin integrity, Acetylarginyltryptophyl Diphenylglycine combats sagging and improves elasticity. It protects elastin and other ECM components against degradation while promoting the production of type I collagen. It is a safe and effective ingredient that restructures connective tissue incorporated in products used to reduce sagging of the chest, neck, and body.Related ingredients
