BoNT-L peptide (Palmitoyl Hexapeptide-19) is a synthetic lipo-peptide with a Botox-like effect and without the side effects of invasive treatment. In comparison with Botox, it has several advantages such as:
- Painless, non-invasive topical treatment
- Cost-effective
- Result-driven
BoNT-L peptide effectively blocks the signal from nerves to facial muscles, preventing contractions and deep wrinkles formation. The signal is transmitted via neurotransmitter molecules (acetylcholine) releasing it into a synaptic cleft (a neuro-muscular connection).
Incorporated in anti-aging formulations, Palmitoyl Hexapeptide-19 provides a safe and effective solution, smoothing fine lines and wrinkles and exposing younger-looking appearance. Acting on a Snare complex level, it just blocks neurotransmitter release, so the action is reversible without any permanent changes in the skin physiology.
Ingredients
What is the Snare complex?
A cascade of a trio of the SNARE proteins: synaptobrevin/VAMP, SNAP 25 (Synaptosomal Associated Protein), and Syntaxin (STNX) forms a complex with the ATPase NSF called SNARE complex.
The SNARE complex is involved in the trafficking of the synaptic vesicle containing neurotransmitters like acetylcholine to the presynaptic membrane. Fusion and exocytosis of the neurotransmitters occur, transmitting the signal from neuron to muscle for contraction.
How does BoNT-L inactivate the SNARE complex?
BoNT-L-peptide binds to SNAP-25 from the SNARE complex, preventing the fusion of the acetylcholine-filled vesicle with the plasmatic membrane. In its turn, it prevents the release of acetylcholine into the synaptic cleft between the nerve and muscle.
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