Bakuchiol is a phenol derived from the Psoralea corylifolia plant used in oriental medicine. The first natural alternative to retinol. Structurally, Bakuchiol is phenol, 4-[(1E,3S)-3-ethenyl-3,7-dimethylocta-1,6-dienyl]phenol. Given the fact that Retinol and Bakuchiol do not have close structural similarities, yet exhibit a similar pattern of activity on certain key anti-aging genes and proteins, is remarkable.
Bakuchiol delivers all of the benefits in a natural form. Over 99% pure, the natural extract from the seeds and leaves of the Psoralea corylifolia plant dramatically reduces hyperpigmentation and dark spots, diminishes the appearance of fine lines and wrinkles, and guards against free radical damage.
In comparison with Retinol, Bakuchiol has excellent photochemical and hydrolytic stability, a good safety profile, and is easy to formulate due to its miscibility with a wide variety of emollients and solubilizers. Taken together, DNA microarray, qtPCR results, cell culture, enzyme inhibitory activity studies, and in-vitro and in-vivo studies carried out on acne-affected skin demonstrate the potential of this true retinol-like compound (highly purified Bakuchiol) to become a key ingredient for dermatological or skin care and treatment products.
Pending an anti-aging clinical study and based on the data generated so far, it is quite conceivable to conclude that Bakuchiol is going to have positive effects on the skin in reducing fine lines and wrinkles with the advantages but without the side effects of retinol. Although this will not entirely fulfill the quest for eternal youth, it may bring it just a step closer.