Ethyl Panthenol

Energizing agent
Regeneration booster
Hair growth stimulator
Hair conditioning
CAS Number(s)
EINECS number(s)

Ethyl Panthenol (or Panthenyl ethyl ether) is the ethyl ether derivative of Panthenol (provitamin B5). Relatively stable to oxygen and light, slightly hygroscopic, stable in neutral or slightly acidic (pH 4 - 7,5), less stable in acidic and alkaline aqueous solutions by hydrolytic cleavage, excessive exposure to heat exceeding 70°-75° C may cause racemization D-Panthenyl ethyl ether is specially designed for cosmetic preparations that are mostly ranging between pH 5 and pH 7.

Panthenyl ethyl ether is reasonably stable to the usual sterilization time in aqueous solutions and before mentioned pH environment. It is a clear, colorless, light yellow, viscous liquid with a faint, characteristic odor and bitter taste. As a result of the presence of an ethyl group, the penetration into hair and skin is enhanced, and the moisturization effect is increased.

Panthenyl ethyl ether is easily soluble in water, alcohol, propylene glycol, and glycerin, readily miscible in some typical cosmetic oils such as f.i. corn oil, sunflower oil, peanut oil, and castor oil, insoluble in paraffin oil, di-/Cyclomethicone, fats, and mineral oil. Among the derivatives of pantothenic acid, Panthenyl ethyl ether offers significant advantages with its acceptable viscosity (no warming-up), a wide range of solubility, and lack of stickiness also in higher concentrations.

Ethyl Panthenol is an ideal addition to D-Panthenol used in many hair care products. With its low viscosity, it can be easily incorporated into all the usual types of formulations. It is metabolized in the skin into Pantothenic acid like Panthenol, the most popular provitamin in personal care products, so the biological mode of action is very similar.

The Pantothenic Acid is then incorporated as an essential component in Coenzyme A, which plays a central role in the metabolism. By virtue of the central role of pantothenic acid in the metabolism, Ethyl Panthenol, as a supplement to D-Panthenol, is one of the most important active agents in beauty care.

Role in Hair Care

  • Increased penetration into the hair shaft
  • Long-lasting moisturization
  • Enhancement of hair strength, increasing the resistance to breakage
  • Prevention of damage caused by overheating and overdrying of the hair and the scalp
  • Conditioning without build-up
  • Synergistic effect with Panthenol and Phytantriol


Panthenyl ethyl ether
Dex-Ethyl Panthenol
D-Panthenyl Ethyl Ether
Dextrorotatory Ethyl Panthenol

Ingredient products

MBR® Medical Beauty Research
MBR® Medical Beauty Research

Ethyl Panthenol has excellent physical (solubility, anti-electrostatic, etc.), chemical (stability), and biological (transcutaneous absorption, etc.) properties. When applied to the skin directly or in cosmetic formulations, it is rapidly absorbed and changed into pantothenic acid (a constituent of coenzyme A) by hydrolysis and oxidation.

In skin care, pantothenic acid stabilizes the skin surface's metabolism, retains the skin's natural moisture balance, penetrates well into deeper skin layers, and stimulates the formation of skin pigments.

In hair care, it improves the combability of wet hair, penetrates well into the hair shaft, causes long-lasting moisturizing effects, promotes gloss and elasticity, improves hair structure, and has a repair effect.

Recommended concentrations for cosmetic use: With concentrations of 0.5% to 5%, Panthenyl ethyl ether can be used alone or with other active ingredients to develop an extensive series of highly effective cosmetic product concepts.

What are the benefits of Ethyl Panthenol (Ethyl provitamin B5)?

Ethyl Panthenol exhibits excellent deposition and penetration in the hair without appearing greasy. As a result of the deposit on and penetration of Panthenyl ethyl ether in the hair, a good water retention capacity remains over a long period. The moisturizing effect is of particular interest since it is mainly in the first two hours after the hair-care procedure that the hair is exposed to the stress of combing, brushing, blow-drying, and permanent-wave treatments.

The high water content of the hair helps to avoid damage to the hair. This is especially the case with damaged hair. Therefore, ethyl Panthenol as an ingredient in shampoos, conditioners, hair rinses, hair lotions, and scalp treatments not only improves the gloss, firmness, and sleekness of the hair but also protects it from mechanical damage and, in general, makes it more resistant to harmful environmental influences.