Saccharomyces Ferment Lysate Filtrate

The extracellular matrix of human skin is comprised of collagen, elastic fibers (of which elastin is a major component), and basement membrane-associated macromolecules such as proteoglycans, fibronectin, and laminin. As skin ages both intrinsically and through photoaging the aging process is manifested on the skin as the visible signs of aging including, sagging of the skin, wrinkles, and loss of skin elasticity.

In addition to these visible changes, the foundation of the extracellular matrix deteriorates as well. Cosmetic science is the art and science of visibly improving these signs of age.

It has been suggested that extracts from Saccharomyces cerevisiae (i.e., Baker's yeast) that have been grown under conditions of cellular stress such as energy sources like heat or UV light, or application of toxic materials such as hydrogen peroxide causes the yeast to respond and produce defensive cellular components that protect the cell from the stress. The stress response of yeast, a typical eukaryotic cell, has many similar characteristics to the stress response that human fibroblasts also undergo when stressed. As a consequence of this, isolation and use of yeast-based stress shock elements in cosmetics has been known for some time and these active components are presently employed in various commercial cosmetic products.

The characteristics of the yeast stress response can be influenced by the growth peptone that the yeast is grown in. For example, it was recently suggested that yeast could be made to express a yeast-based epidermal growth factor very similar to a human epidermal growth factor. This has created an opportunity to modify the yeast cellular response through manipulation of the yeast growth media to stimulate yeast to produce various cytokines and growth factors similar to human-based factors. Such factors might include, for example, Tissue Growth Factor Beta (TGFb), Interleukin la (IL-la), and Epidermal Growth Factor (EGF) all of which play key roles in the growth of healthy skin.

Saccharomyces Ferment Lysate Filtrate is enriched in a variety of unique human-like cytokines and growth factors. This yeast lysate still maintains the ability to stimulate cellular oxygen uptake that has characterized stress yeast lysates. However, through careful control of our yeast fermentation growth technology and growth media, produced Saccharomyces Ferment Lysate Filtrate stimulates the production of soluble elastin from human fibroblasts.

Regeneration booster
Skin conditioning
Biodynes® EMPP (Extracellular Matrix Promoting Peptone)