Dimethyl Isosorbide (2,5-dimethyl isosorbide; 1,4:3,6 dianhydro-2,5-di-o-methyl-D-glucitol) is a water-white liquid with excellent solvent properties that can solubilize poorly water-soluble active ingredients. It has undergone extensive studies for topical and even oral drug delivery and has been shown to be completely safe for use.
It has been safely used in personal care applications for years, and several medicinal products containing Dimethyl Isosorbide are already commercialized in the EU and USA. It is stable to hydrolysis, miscible with all proportions of water without hydrolyzing, and not hydrolyzes at acidic pH.
Dimethyl Isosorbide is soluble in all proportions in water and other commonly used cosmetic and pharmaceutical ingredients. It is miscible with most organic solvents and non-ionic surfactants. Therefore, it can be easily formulated into various cosmetic and pharmaceutical forms, including lipid-based self-micro emulsifying drug delivery systems.
Dimethyl isosorbide also enhances penetration through the epidermis. It improves the stability of formulations, even those susceptible to hydrolysis or transesterification. It does not require specialized equipment for manufacture, and there is no need for the flammable handling equipment required for many other commonly used solvents.Related ingredients
