Functions
Preservative
Anti-dandruff
Anti-Seborrheic
Antiseptic
CAS Number(s)
659-40-5
EINECS number(s)
211-533-5
FDA UNII
023XA5Z50L
Hexamidine Diisethionate is a water-soluble antimicrobial cationic polyvalent preservative with a wide spectrum of protection against bacteria, fungi, and yeasts.
Hexamidine Diisethionate has significant microbiostatic and/or microbicidal action against:
- Gram-positive bacteria: Staphylococcus, Sarcina, Streptococcus, Corynebacterium, Propionibacterium, Bacillus
- Gram-negative bacteria: Escherichia, Proteus, Klebsiella, Salmonella, Serratia
- Gram-negative bacteria, oxidase-positive: Pseudomonas
- Fungi: Aspergillus, Penicillium, Actinomyces, Geotrichum, Trichophyton, Hormodendron
- Yeasts: Candida, Pityrosporum.
The antimicrobial effects of Hexamidine Diisethionate vary according to the:
- the concentration and duration of contact with the anti-microbial agent
- the number of micro-organisms
- the nature and virulence of the germs
- the properties and characteristics of the formula
Synonyms
Elestab™ HP 100
Microbiox
F.A.Q.
It Hexamidine diisethionate effective against dandruff?
Hexamidine diisethionate is a poly-valent preservative with a particularly broad anti-microbial spectrum against bacteria, yeasts, and molds. Two special properties led to testing its anti-dandruff efficacy in a clinical study: its cationic character, guaranteeing a good substantivity to hair and scalp, and its efficacy against Malassezia furfur, a fungus considered to be the most common cause of dandruff.
A clinical study was carried out on 32 volunteers, using a shampoo containing 0.1% Hexamidine diisethionate every day for 4 weeks, against a placebo and positive control (zinc pyrithione at 1 %). Evaluations by the users have shown that:
- The anti-dandruff effect is visible after 1 week and increases during the 4 weeks of treatment.
- The obtained efficacy is at least as good as the positive control, and the effect is maintained 2 weeks after ending the treatment for more than 70% of the persons, better than zinc pyrithione.
- The tested shampoo was overall appreciated by more than 70% of the volunteers for its efficacy to improve the state of the scalp: diminishing dandruff, reducing itching, and delaying the time it takes to get greasy again. Quite impressive for a rinse-off product!
What are the benefits and advantages of Hexamidine Diisethionate?
- Effective antiseptic against the fungus Malassezia furfur, which causes dandruff seborrheic dermatitis
- Antibacterial action against the bacteria Propionibacterium acnes and Staphylococcus epidermidis helps to control acne
- Regulates scalp and skin sebum production
- Can be used in deodorant, neutralizes microorganisms responsible for underarm odor
- Broad-spectrum antimicrobial agent
- Easily incorporated into formulations, as it is a transparent and water-soluble liquid
- Can be used as a preservative in cosmetic formulations
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