Functions
Preservative
Anti-dandruff
Anti-Seborrheic
Antiseptic
CAS Number(s)
659-40-5
EINECS number(s)
211-533-5
FDA UNII
023XA5Z50L
INCI name
Hexamidine Diisethionate
Hexamidine Diisethionate is a water-soluble antimicrobial cationic polyvalent preservative with a wide spectrum of protection against bacteria, fungi, and yeasts.
Hexamidine Diisethionate has significant microbiostatic and/or microbicidal action against:
- Gram-positive bacteria: Staphylococcus, Sarcina, Streptococcus, Corynebacterium, Propionibacterium, Bacillus
- Gram-negative bacteria: Escherichia, Proteus, Klebsiella, Salmonella, Serratia
- Gram-negative bacteria, oxidase-positive: Pseudomonas
- Fungi: Aspergillus, Penicillium, Actinomyces, Geotrichum, Trichophyton, Hormodendron
- Yeasts: Candida, Pityrosporum.
The antimicrobial effects of Hexamidine Diisethionate vary according to the:
- the concentration and duration of contact with the anti-microbial agent
- the number of micro-organisms
- the nature and virulence of the germs
- the properties and characteristics of the formula
Synonyms
Elestab™ HP 100
Microbiox
F.A.Q.
It Hexamidine diisethionate effective against dandruff?
Hexamidine diisethionate is a poly-valent preservative with a particularly broad anti-microbial spectrum against bacteria, yeasts, and molds. Two special properties led to testing its anti-dandruff efficacy in a clinical study: its cationic character, guaranteeing a good substantivity to hair and scalp, and its efficacy against Malassezia furfur, a fungus considered to be the most common cause of dandruff.
A clinical study was carried out on 32 volunteers, using a shampoo containing 0.1% Hexamidine diisethionate every day for 4 weeks, against a placebo and positive control (zinc pyrithione at 1 %). Evaluations by the users have shown that:
- The anti-dandruff effect is visible after 1 week and increases during the 4 weeks of treatment.
- The obtained efficacy is at least as good as the positive control, and the effect is maintained 2 weeks after ending the treatment for more than 70% of the persons, better than zinc pyrithione.
- The tested shampoo was overall appreciated by more than 70% of the volunteers for its efficacy to improve the state of the scalp: diminishing dandruff, reducing itching, and delaying the time it takes to get greasy again. Quite impressive for a rinse-off product!
What are the benefits and advantages of Hexamidine Diisethionate?
- Effective antiseptic against the fungus Malassezia furfur, which causes dandruff seborrheic dermatitis
- Antibacterial action against the bacteria Propionibacterium acnes and Staphylococcus epidermidis helps to control acne
- Regulates scalp and skin sebum production
- Can be used in deodorant, neutralizes microorganisms responsible for underarm odor
- Broad-spectrum antimicrobial agent
- Easily incorporated into formulations, as it is a transparent and water-soluble liquid
- Can be used as a preservative in cosmetic formulations
Related ingredients
Bakuchiol is a derivative from the psoralea corylifolia plant used in oriental medicine. The first natural alternative to retinol.
As a C22 quat, Behentrimonium chloride belongs to the Behenyl class of surfactants. Lower irritation, more conditioning, better thickening, enhanced skin feel, and improved stick structure are all characteristics of this group of ingredients.
Benzyl Cinnamate is a 16-carbon ester (cinnamic acid benzyl ester) commonly used in the food industry as a flavor enhancer in non-alcoholic beverages, baked goods, and candy. It is a white-to-pale-yellow solid insoluble in water.
Cimicifuga racemosa is my herb of choice for PMS, pre-menopausal and menopausal conditions, also in breast enlargement formulas thanks to its estrogenic action.
Burdock, officially called Arctium lappa, is considered a healthy and nutritive food in China. Arctium lappa was used as a medicinal herb in Europe, North America, and Asia for centuries.
C12-15 Alkyl Benzoate is an emollient ester produced from Benzoic Acid and fatty alcohols with 12-15 carbon atoms
Calendula oil also has antiseptic, anti-fungal, and anti-inflammatory properties. It is a very gentle and soothing oil.
Capryloyl glycine is an amide of Glycine (amino acid) and Caprylic acid (a fatty acid that contains eight carbon atoms in the chain). It's a member of the N-acyl glycines family, normally occurring in human tissues, so it's a safe component for skin care formulations.
Commonly referred to the as clear eye, the sticky solution derived from clary seeds has long been used to rid the eyes of foreign matter and to soothe as a natural demulcent.
Coltsfoot extract is a natural skincare ingredient is high in polysaccharides, vitamin C, and Zinc. It stimulates dermal regeneration and leaves soothing, softening, and antioxidant effects—a natural remedy for youthful and glowing skin.
This adorable oil has antimicrobial, antioxidant, anti-inflammatory, and anti-aging effects. Rosa damascena has a wide spectrum of antimicrobial activities against many species of harmful bacteria. Like many other aromatic and medicinal flowers, it shows antioxidant properties.
Elderflower (Sambucus nigra flower) extract is extracted from organically grown flowers. The elder has been called‘ the cosmetic tree’ by some herbalists since nearly all the parts of it can benefit the skin. The flowers are used for a variety of skin problems, especially on inflammation or broken skin.