Acetyl Glycyl Beta-Alanine is a synthetic peptide, a multifactorial skin whitening agent that suppresses different steps of melanin production. It is known under the trade name GenoWhite™.
Thanks to its high chemical stability, Acetyl Glycyl Beta-Alanine is tolerant to light and heat. It has a high safety profile and exhibits no phototoxicity or photosensitizing capacity.
Acetyl Glycyl Beta-Alanine inhibits the activity of two proteins, Stem Cell Factor (SCF) and Endothelin-1 (ET-1), factors that increase gene expressions at the epidermal level after UVB irradiation, resulting in several responses from the skin, including induction of pigmentation.
In addition, Acetyl Glycyl Beta-Alanine reduces the gene expression of MITF (Microphthalmia Transcription Factor), one of the most important transcription factors that regulate the development and survival of melanocytes and which is involved in the transcription of the genes of enzymes essential for the melanin production such as tyrosinase, TRP1, and TRP2. In short, it reduces the concentration of critical enzymes crucial for the melanogenesis process.Scientific studies showed that Acetyl Glycyl Beta-Alanine effectively lessens:
- Tyrosinase up to 40%
- Tyrosinase-related protein-1 (TRP-1) up to 42.1%
- Tyrosinase-related protein-2 (TRP-2) up to 91.9%.
Furthermore, it decreases the transfer of melanin to keratinocytes by up to 45%. Acetyl Glycyl Beta-Alanine fights against hyperpigmentation, dark spots, and other discoloration concerning excessive melanin production. It is used in many modern skin whitening, anti-aging, and after-sun products.
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