Caprooyl tetrapeptide-3, also marked as KGHK-Caproic acid, is a biomimetic lipopeptide structure based on TGF-ß (transforming growth factor beta) that plays an essential role in the natural production of the extracellular matrix components. The peptide sequence is Lys-Gly-His-Lys. It decreases the appearance of fine lines & wrinkles, improves skin elasticity, and fights against stretch marks.
A research study showed that caprooyl tetrapeptide-3 boosts the production of DEJ (dermal-epidermal junction) structural proteins such as laminin up to 26% and fibronectin up to 60%, improving mechanical properties of the skin. In another research with a model of skin aging, tetrapeptide-3 enhanced the expression of genes responsible for collagen VII and laminin-5 production. Both proteins are required for stronger adhesion of the epidermis to the dermis at the DEJ.
Caprooyl tetrapeptide-3 as an active ingredient in ChroNOline™ was tested in the placebo-controlled clinical study to reduce fine lines and wrinkles. Participants were a group of 27 women volunteers aged 40-65. A face cream based on ChroNOline™ showed a significant (up to 27%) decrease in the appearance of fine lines and wrinkles. In addition, participants also spontaneously described prompt anti-aging results such as increased skin smoothness, firmness, and a younger-looking appearance.