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ChroNoline (Caprooyl tetrapeptide-3) is a specially formulated amino acid combination tetrapeptide (a biomimetic growth factor derivative), which recreates growth factors found in youthful skin, increasing dermo-epidermal junction (DEJ -key components production to maintain optimal skin structure). It is a state-of-the-art biomimetic tetrapeptide, which stimulates collagen synthesis and has a positive effect on the dermal-epidermal linkage and the synthesis of laminin-5 maintaining the integrity and preventing flattening of the DEJ

ChroNOline induces fibronectin production by 60% and thus firmly anchors cells to the matrix for optimal cell functions. What is more, it also strengthens the connection between the epidermis and dermis, i.e., the "plumping effect coming from the deeper layers." The active ingredient was convincing in tests, on average attaining a reduction of fine lines and wrinkles of 47 %.

Caprooyl tetrapeptide-3 provides a long-term significant reduction in the appearance of fine lines & wrinkles in mature skin. It is easy to use ingredient with an exceptional safety profile, preservative-free peptide prepared in plant-derived glycerine.

Active ingredients (or INCI)

Caprooyl tetrapeptide-7

Ingredient products

MBR® Medical Beauty Research
MBR® Medical Beauty Research
MBR® Medical Beauty Research
MBR® Medical Beauty Research
MBR® Medical Beauty Research

Mechanism of action

Genetic dispositions, UV exposure, and pollution lead to the dynamic and complex phenomenon of skin chronological aging. Skin aging is characterized by the loss of elasticity, support, and firmness, skin fragility, and the appearance of fine lines and wrinkles. At the cellular level, skin aging leads to a decrease in epidermal thickness, combined with a flattening of dermo-epidermal junction (DEJ) which decreases the number of nutrients available to the epidermis thus interfering with the skin’s natural repair process.

DEJ's major components are:

  • Laminin-5: Anchors the epidermis to the dermis for structural support
  • Collagen VII: Anchors the dermis to the DEJ for mechanical stability of the DEJ
  • Fibronectin: Anchors cells to ECM for cell adhesion.

CroNOline™ is the solution Caprooyl tetrapeptide-7 derived from a growth factor peptide linked to a lipid for higher stability and optimal skin penetration. It boosts the production of key components at the DEJ like collagen VII, laminin-5, and fibronectin for optimal skin structural support. CroNOline™ provides an outstanding reduction of the appearance of fine lines and wrinkles after only 28 days.

The DEJ provides structural and functional integrity to the skin. Unfortunately DEJ flattens and becomes linear during aging, contributing to wrinkle formation. Collagen VII and laminin-5 are major constituents of the DEJ. They both help to maintain skin cohesion thus preventing wrinkle formation.