D-Arginyl Tyrosinyl Ornithinyl Phenylalanine

Functions
Targeting
Skin conditioning

D-Arginyl Tyrosinyl Ornithinyl Phenylalanine is a synthetic tetrapeptide with sequence D-Arg-Tyr-Orn-Phe-NH2 similar to Szeto–Schiller (SS) peptides. Szeto–Schiller peptides are tetrapeptides that showed promising results against a wide range of mitochondrial disorders and are considered able to target mitochondrial membranes.

D-Arginyl Tyrosinyl Ornithinyl Phenylalanine is the analog of widely studied Szeto–Schiller peptides SS-31 with sequence D-Arg-Dmt-Lys-Phe-NH2 and mtCPP-1 with sequence D-Arg-Dmt-Orn-Phe-NH2 (where Dmt is Dimethyltyrosine, an analog of Tyrosine and Orn is Ornithine structurally close to Lysine) used to designed mitochondria-targeting peptide conjugates.

Thanks to its ability to target mitochondria, D-Arginyl Tyrosinyl Ornithinyl Phenylalanine is used in an advanced delivery system with a trade name Trojan® that targets skin cell organelles (mitochondria). Connected with covalent bonds to hydroxy groups of a polymeric capsule from Lactic Acid/Glycolic Acid Copolymer (PLGA), this guiding peptide helps to deliver encapsulated active ingredients directly to mitochondria.

Thanks to targeted action, D-Arginyl Tyrosinyl Ornithinyl Phenylalanine dramatically boosts the effectiveness of the complex, functionalizing the polymeric capsule, delivering actives into cell organelle, and allowing to minimize their concentration. It provides sustained and managed release of active ingredients in the target cells and even in the target organelle.

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