Hexapeptide-48 HCl

Hexapeptide-48 HCl is a synthetic peptide, known under the trade name Rubixyl®, that acts as a specific agonist for the delta opioid receptors. The expression of the delta opioid receptor is modulated in inflammatory conditions and stress.

Inflammatory stress leads to the dysregulation of the expression of genes and proteins involved in the maintenance of epidermal integrity and the barrier function of the epidermis. Hexapeptide-48 HCl is an anti-stress peptide and is capable of blocking the depletion of the delta opioid receptor in inflammatory conditions.

Topical application the preparation containing Hexapeptide-48 HCl regulates the expression of regulated genes and proteins. In addition, it diminishes the influence of chronological stress aging and cigarette smoke-induced skin stress.

In vitro and in vivo studies showed that activation by a natural agonist of the delta opioid receptor Hexapeptide-48 HCl reduces skin inflammation while improving epidermal differentiation and barrier function. The study on healthy volunteers confirmed the effectiveness of the Rubixyl peptide in repairing damaged skin by allowing a reduction in TEWL, an increase in hydration, and a reduction in wrinkles, including in the perioral (around the mouth) and eye areas.

Hexapeptide-48 HCl is used in high-end anti-aging, anti-wrinkle, and eye-care products in concentrations of 0.1-2%.

Functions
Anti-aging
Soothing
Hydrating
Barrier enhancer
Skin conditioning
Synonyms
Rubixyl®

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