Nicotinoyl Dipeptide-23

Functions
Skin whitening agent
Skin conditioning

Nicotinoyl Dipeptide-23 is a vitamin-peptide conjugate niacinamide (Vitamin B3) introduced into the N-terminus of peptide through chemical synthesis. It is known under the trade name V-peptide-2.

Niacinamide is a raw material known for its skin-whitening effect, and peptide (consisting of proline and serine) plays a role in potentiating (doubling) the whitening effect.

Suppressing the production of MITF from the nucleus, Nicotinoyl Dipeptide-23 lessens the direct synthesis of melanin by inhibiting the activity of Tyrosinase 1 and 2 enzymes. MITF, a Mirophthalmia-Associated Transcription Factor, is an essential transcriptional regulator in the melanin synthesis process that promotes tyrosinase production. Those enzymes (Tyrosinase 1 and 2) are involved in the most critical initial rate-determining step in the melanin biosynthesis pathway.

In addition, Nicotinoyl Dipeptide-23 inhibits the transfer of already produced melanosomes from melanocytes to keratinocytes, brightening and unifying the skin tone. It is a safe and effective skin whitening agent for high-end skincare applications that fights against hyperpigmentation, dark spots, and discolorations.
See also
Synonyms
V-peptide-2

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