Nonapeptide-1

Functions
Skin whitening agent
Hair conditioning
Skin conditioning
CAS Number(s)
158563-45-2
FDA UNII
64W45420K5

Nonapeptide-1 is a synthetic biomimetic peptide that acts as an antagonist of α-MSH (melanin-stimulating hormone). It is found by screening methods using different parts of the α-MSH sequence and testing for their ability to block specific MC1-R receptors on melanocytes.

The most potent peptide was the Nonapeptide-1, which repeats a small part of the sequence (H-Met-Pro-D-Phe-Arg-D-Trp-Phe-Lys-Pro-Val-NH2) of α-MSH and occupies an MC1-R receptor, preventing its activation by the hormone and lessening melanin production by 33%. It prevents the activation of tyrosinase, a crucial enzyme involved in melanin synthesis.

Thanks to its antagonizing action, Nonapeptide-1 is an excellent skin-lightening agent without cytotoxicity or interference with melanocyte functions. It does not totally inhibit melanogenesis, which opposes the hyper-production of melanin pigment.

Incorporated in skin care applications, Nonapeptide-1 reduces sun and dark spots, freckles, and hyperpigmentation, exposing a lighter, whiter, and radiant complexion with an even skin tone. It is a stable, effective, and safe peptide that significantly reverses hyperpigmentation and equalizes skin tone in only 28 days.
Synonyms
Melanostatine™ 5

Related ingredients

1,2-Hexanediol
1,2-Hexanediol
1,2-Hexanediol is glycol alcohol (with two hydroxy groups on 1 and 2 positions and six carbon atoms), a multifunctional ingredient used as a solvent, emollient, moisturizing agent, and preservative in skin and hair care applications.
Abyssinian Oil
Abyssinian Oil
Abyssinian oil (Crambe oil) achieves a significant improvement on the surface structure as well as the evenness of the skin tone.
Acetyl Dipeptide-1 Cetyl ester
Acetyl Dipeptide-1 Cetyl ester
This lipopeptide exhibits good stimulating results on elastin production. As a result, Acetyl Dipeptide-1 Cetyl ester fights against cutaneous sagging and decreases the visible effects of gravity on the skin.
Acetyl Heptapeptide-9
Acetyl Heptapeptide-9 mimics the TGFβ. Acetyl Heptapeptide-9 effects on fibroblasts, stimulating collagen, elastin, and other components of ECM production.
Acetyl octapeptide-3
Acetyl octapeptide-3
Acetyl Octapeptide-3 is a brilliant, new, deep penetrating, powerful amino-peptide with a fantastic ‘BOTOX® like’ effect.
Adenosine 5 Triphosphate (ATP)
Adenosine 5 Triphosphate (ATP)
Naturally existing in our bodies as part of the molecule adenosine triphosphate (ATP), responsible for transporting energy for numerous cellular and muscular functions in our body
Alanine
Alanine
Alanine is an amino acid permanently produced in the human body. It is included in beauty formulations as an effective skin humectant.
Alaria esculenta extract
Alaria esculenta extract
Rich in antioxidant oligosaccharides protects the skin from UV-induced damage and oxidative stress. Alaria esculenta extract has a skin-lightening effect similar to vitamin B3.
Algae Extract
Algae Extract
Contains micro-nutrients such as iron, manganese, zinc, magnesium, copper.
Alistin®
Alistin®
Alistin® (Decarboxy Carnosine) is a synthetic antiaging pseudodipeptide with high stability and resistance to enzymatic hydrolysis, that cell membranes oxidative stress and dermal fiber from cross-linking.
Alpha-Glucan Oligosaccharide
Alpha-Glucan Oligosaccharide
Thanks to the specificity of its inter-glycosidic bonds, Alpha-Glucan is a selective substrate for the nutrition and development of the skin's saprophytic (beneficial) flora to the detriment of undesirable opportunists flora (pathogenic or not) ready to invade the skin at the slightest sign of imbalance.
Alpha-isomethyl Ionone
Alpha-isomethyl Ionone
Alpha-isomethylionone is a colorless to pale oily liquid, an isomer of Methyl Ionone, but its sweet orris-like scent is felt more attractive.