Palmitoyl Hexapeptide-12

Skin conditioning
CAS Number(s)

Palmitoyl Hexapeptide-12, also known as Biopeptide El™, is a conjugate of Palmitic acid and a peptide with a sequence Val-Gly-Val-Ala-Pro-Gly, known as a fragment of the protein called elastin. It is the most frequently repeated (six times) sequence, a "spring fragment" in elastin that boosts the production of collagen, elastin, fibronectin, and glycosaminoglycans (GAGs).

Palmitic acid attached to peptide to yield more lipophilic structure considerably enhances the skin penetration levels, efficiency, and power. It enables potentiation or even initiation of the cosmetic activity that requires the transport of the peptide to the living tissues of the skin.

Hexapeptide-12 has chemotactic property, attracting skin fibroblasts to a site of inflammation or cicatrization and stimulating mobility. Additional research revealed that this peptide, in particular its derivatized form, Palmitoyl Hexapeptide-12, is endowed with unsuspected cosmetic activities, namely a firming, tone improvement, and restructuring effect on the skin of the neck and face.

In addition, the Biopeptide El™ restructuring effect also contributes to enhanced moisturization of the skin. Newer research showed that concomitant use of the peptide and Ceramide NG in cosmetic or skin care compositions (Dermaxyl™) enhances the anti-aging effect, barrier function, and hydration levels.
Glycine, N-(1-oxohexadecyl)-L-valylglycyl-L-valyl-L-alanyl-L-prolyl-