Palmitoyl Hexapeptide-52

Palmitoyl Hexapeptide-52 is a synthetic lipopeptide that inhibits acetylcholine release into the synaptic cleft and expression muscle contractions. It is a core peptide in an advanced peptide-based complex X50® Myocept, which has a Botox-like effect against expression lines.

Common facial expressions can increase the appearance of deep wrinkles and skin aging. These expressions depend on muscle contractions, which in turn are linked to the transmission of information by the neuronal cells of the skin. Botox® (Botox® is a registered brand by Allergan®) and other derived peptides, well recognized in the cosmetic market for anti-wrinkle treatment, act by inhibiting the release of neurotransmitters from the neuron, inhibiting muscle contraction. However, Botox® only penetrates the skin by injection, and derived peptides are effective at high concentrations.

X50® Myocept is a cell-targeted polymeric capsule (Cosmetic Drone®) containing Palmitoyl Hexapeptide-52. It suppresses signal transfer from neurons to facial muscles, relaxing, blocking contractions, and smoothing expression lines and wrinkles.

X50® Myocept contains a double active (Palmitoyl Hexapeptide-52 and Palmitoyl Heptapeptide-18 as a targeting peptide) with synergistic action inhibiting muscle contraction. Thanks to its high penetration and selectivity, it achieves a 20% reduction in the depth and length of the wrinkle at very low doses (0.001%) and without injections.