Palmitoyl Tripeptide-53 Amide

Functions
Skin whitening agent
Soothing
Skin conditioning
CAS Number(s)
2170645-13-1
FDA UNII
06VMR2935X

Palmitoyl Tripeptide-53 Amide (known under the trade name Winhibin™) is a low molecular-weight tripeptide derived from Sfrp5 (Secreted frizzled protein5) and known as a modulator adipokine of WNT-signaling. Winhibin peptide fights against skin hyperpigmentation and works as a skin-whitening agent.

Palmitoyl Tripeptide-53 Amide acts as an antagonist of the Wnt signaling pathway. It suppresses Microphthalmia-associated Transcription Factor (MITE) expression by promoting 13-catenin degradation. As a result, it inhibits melanogenesis exposing a uniform, brighter, and radiant complexion.

Furthermore, Palmitoyl Tripeptide-53 Amide can suppress the production of proinflammatory cytokines such as TNFα, and interleukin-1β by repressing Wnt/JNK signaling pathway.

Incorporated in skin care applications, Palmitoyl Tripeptide-53 Amide helps to reduce skin pigmentation as well as the formation of freckles and blemishes, thereby exerting skin-lightening and clarifying effects. In addition, it delivers skin-soothing effects by reducing pro-inflammatory 13-catenin production.
Synonyms
Winhibin™
D-Lysinamide, N-(1-oxohexadecyl)-D-alanyl-D-glutaminyl-

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