Pentapeptide-25 is a synthetic peptide that retreats the sequence (Lys Val Arg Leu GIn) of a member of the UCP family of proteins found in mitochondria. "UCP" refers to a family of Uncoupling Proteins in various human tissues, including adipocytes (fatty cells). UCP proteins play a significant role in energy metabolism and the metabolic regulation of triglycerides. Significant gene therapy research has been conducted into using UCP proteins to treat genetic dysfunctions and diseases related to obesity and diabetes.
When applied to the skin, these UCP proteins have a slimming effect, reducing, eliminating, and preventing excessive subcutaneous fat. Pentapeptide-25 mimics the action of UCP proteins, opening new prospects, particularly in topical use to fight cellulite.
Excessive triglyceride storage can generate enlarged fat cells and, thus, body fat. Pentapeptide-25 significantly contributes to a decrease in the quantity of triglycerides in the skin's fat and cellulite formation. So, the skin gradually regains its normal appearance and does not develop cellulite tissue, making it possible to prevent and treat the appearance of cellulite.
Pentapeptide-25 can be used in a cream, suspension, or powder and is adapted for application to the skin, mucous membranes, lips, hair, and nails. It can also be applied in lotions, milk, serums, ointments, shampoos, gels, pastes, and mousse or as key ingredients in skin care products. Another advantage of this ingredient is that it offers an effective topical treatment against body fat while using noninvasive, nonsurgical, and relatively inexpensive methods.