sh-Oligopeptide-4

sh-Oligopeptide-4 is a synthetic recombinant Thymosin-β4 peptide that helps strengthen hair while stimulating hair follicles to produce healthier hair. Endogenous Thymosin beta-4 (initially found in cow thymus in 1981; consisting of 44 amino acids) is an essential protein that regulates cell migration and differentiation involved in wound healing, regeneration, and angiogenesis, but it is biologically unstable.

A synthetic analog of Thymosin-β4 is more stable and exhibits superior activity and excellent skin permeation thanks to low molecular weight. It increases energy at the hair roots, improves scalp circulation, and encourages hair growth. In addition, sh-Oligopeptide-4 stimulates collagen deposition in the wound and speeds up recovery.

Applied topically, sh-Oligopeptide-4 improves skin condition, smooths wrinkles, and enhances skin elasticity, exhibiting a noticeable anti-aging effect. In addition, it increases the skin's moisture content and fights against dark spots and acne.

sh-Oligopeptide-4 promotes hair growth, stimulating follicle stem cell growth, migration, differentiation, and protease production. A critical step in the hair growth cycle is the movement of some of the bulge-residing stem cells downward, where their differentiated progeny contribute to complete re-growth or regeneration of the lower, cycling portion of the follicle. sh-Oligopeptide-4 facilitates this movement of the stem cells and their immediate progeny and, thus, exerts its promoting effect on hair growth.
Functions
Hair growth stimulator
Skin conditioning
Synonyms
CG-Thymosin-β4
Thymosin beta 4
Human Oligopeptide-16

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