sh-Oligopeptide-4

sh-Oligopeptide-4 is a synthetic recombinant Thymosin-β4 peptide that helps strengthen hair while stimulating hair follicles to produce healthier hair. Endogenous Thymosin beta-4 (initially found in cow thymus in 1981; consisting of 44 amino acids) is an essential protein that regulates cell migration and differentiation involved in wound healing, regeneration, and angiogenesis, but it is biologically unstable.

A synthetic analog of Thymosin-β4 is more stable and exhibits superior activity and excellent skin permeation thanks to low molecular weight. It increases energy at the hair roots, improves scalp circulation, and encourages hair growth. In addition, sh-Oligopeptide-4 stimulates collagen deposition in the wound and speeds up recovery.

Applied topically, sh-Oligopeptide-4 improves skin condition, smooths wrinkles, and enhances skin elasticity, exhibiting a noticeable anti-aging effect. In addition, it increases the skin's moisture content and fights against dark spots and acne.

sh-Oligopeptide-4 promotes hair growth, stimulating follicle stem cell growth, migration, differentiation, and protease production. A critical step in the hair growth cycle is the movement of some of the bulge-residing stem cells downward, where their differentiated progeny contribute to complete re-growth or regeneration of the lower, cycling portion of the follicle. sh-Oligopeptide-4 facilitates this movement of the stem cells and their immediate progeny and, thus, exerts its promoting effect on hair growth.
Functions
Hair growth stimulator
Skin conditioning
Synonyms
CG-Thymosin-β4
Thymosin beta 4
Human Oligopeptide-16

Related ingredients

1,2-Hexanediol
1,2-Hexanediol
1,2-Hexanediol is glycol alcohol (with two hydroxy groups on 1 and 2 positions and six carbon atoms), a multifunctional ingredient used as a solvent, emollient, moisturizing agent, and preservative in skin and hair care applications.
Abyssinian Oil
Abyssinian Oil
Abyssinian oil (Crambe oil) achieves a significant improvement on the surface structure as well as the evenness of the skin tone.
Acetyl Dipeptide-1 Cetyl ester
Acetyl Dipeptide-1 Cetyl ester
This lipopeptide exhibits good stimulating results on elastin production. As a result, Acetyl Dipeptide-1 Cetyl ester fights against cutaneous sagging and decreases the visible effects of gravity on the skin.
Acetyl Heptapeptide-9
Acetyl Heptapeptide-9 mimics the TGFβ. Acetyl Heptapeptide-9 effects on fibroblasts, stimulating collagen, elastin, and other components of ECM production.
Adenosine 5 Triphosphate (ATP)
Adenosine 5 Triphosphate (ATP)
Naturally existing in our bodies as part of the molecule adenosine triphosphate (ATP), responsible for transporting energy for numerous cellular and muscular functions in our body
Alanine
Alanine
Alanine is an amino acid permanently produced in the human body. It is included in beauty formulations as an effective skin humectant.
Algae Extract
Algae Extract
Contains micro-nutrients such as iron, manganese, zinc, magnesium, copper.
Alistin®
Alistin®
Alistin® (Decarboxy Carnosine) is a synthetic antiaging pseudodipeptide with high stability and resistance to enzymatic hydrolysis, that cell membranes oxidative stress and dermal fiber from cross-linking.
Alpha-Glucan Oligosaccharide
Alpha-Glucan Oligosaccharide
Thanks to the specificity of its inter-glycosidic bonds, Alpha-Glucan is a selective substrate for the nutrition and development of the skin's saprophytic (beneficial) flora to the detriment of undesirable opportunists flora (pathogenic or not) ready to invade the skin at the slightest sign of imbalance.
Alpha-isomethyl Ionone
Alpha-isomethyl Ionone
Alpha-isomethylionone is a colorless to pale oily liquid, an isomer of Methyl Ionone, but its sweet orris-like scent is felt more attractive.
Ammonium Lactate
Ammonium Lactate
This food-grade ingredient is valued for its humectant and skin conditioning effects and is used as an anionic surfactant.
Apple extract
Apple extract
The Apple awakens energies and is said to have an exceptionally activating effect on the body. The scent contributes to an extremely refreshing and stimulating sensation.