Boswellia (Boswellia Serrata) is a plant used in traditional Ayurvedic medicine for centuries that promotes joint comfort and has anti-inflammatory action. Boswellia Serrata Resin Extract is an ingredient originating from historical roots that applied modern science to ancient knowledge.
Modern research allowed the identification of the most powerful compound contained in Boswellia Serrata Resin Extract, called AKBA (Acetyl-11-keto-beta boswellic acid, the most potent of all Boswellic acids). Thanks to current processing methods, AKBA can rich up to 30% concentration, ten times more than ordinary extract.
Boswellia Serrata Resin Extract inhibits several inflammatory mediators and enzymes responsible for collagen degradation, an essential component of connective tissues. It inhibits an enzyme called 5-lipoxygenase (5-LOX), which is involved in the inflammation pathway (leukotriene biosynthesis). Its action is very targeted (selective) and non-redox type, so it does not affect other systems. In addition, Boswellia Serrata Resin Extract inhibits ICAM and VCAM, adhesion molecules that are directly involved in inflammation. Endothelial VCAM-1, for example, is a central player in recruiting white blood cells to the area of inflammation.
Inhibiting the production of matrix metalloproteinase (MMP) enzymes, Boswellia Serrata Resin Extract protects the skin's structural proteins and lessens collagen degradation. Applied topically, it exhibits firming, smoothing, and anti-aging effects, exposing a youthful appearance.Boswellia Serrata Resin Extract is a safe ingredient for skin care applications with vast data from historical and modern studies. It is non-irritating for the skin and mildly irritating to the eye. Its acute dermal toxicity is LD50 > 2000 mg/Kg, acute oral toxicity is LD50 > 5000 mg/Kg, and chronic toxicity is LD50 > 2.5 gm/Kg.
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