Methyl Undecenoyl Leucinate

Skin whitening agent
Skin conditioning
CAS Number(s)

Alpha-MSH (melanocyte-stimulating hormone), is best known as a major factor in the regulation of pigmentation through its unique mechanism. Alpha-MSH is involved in the control of tyrosinase activity, melanin synthesis, and melanosome transfer.

Methyl Undecenoyl Leucinate is a lipo-amino acid that interacts with MC1R, a receptor for alpha-MSH, competes against its natural ligand, alpha-MSH, and thereby prevents any further activation of melanogenic genes such as tyrosinase, TRP1, TRP2 (DCT), MITF and POMC and finally blocks melanin production.

In vitro and in vivo study results show that Methyl Undecenoyl Leucinate is far more effective than other known whitening ingredients such as kojic acid, arbutin, and hydroquinone. It is an excellent skin whitening agent for face and body care applications via inhibition of melanogenic pathway. In addition, it leaves an anti-inflammatory effect against environmental stimuli such as UV exposure.

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