Methylisothiazolinone

Functions
Preservative
CAS Number(s)
2682-20-4
EINECS number(s)
220-239-6
FDA UNII
229D0E1QFA

Methylisothiazolinone is a heterocyclic compound from the Isothiazolinone family. It is a white solid fully soluble in water, glycols, and other alcohols.

Methylisothiazolinone is a broad-spectrum, globally acceptable preservative for leave-on and rinse-off personal care products. It is effective against bacteria, mold, yeast, and microalgae in minimal concentrations up to 0.01%. It is used in hair, body, sun care products, perfume, liquid soaps, and other applications.

Exhibiting good antimicrobial effectiveness against Gram-negative and -positive bacteria, Methylisothiazolinone is active in a wide range of pH values and compatible with almost all types of surfactants (anionic, cationic, and nonionic), proteins, and other antiseptics, including fungicides.

Combined with other preservatives of the Isothiazolinone family, like Methylchloroisothiazolinone, Methylisothiazolinone improves preservation effectiveness thanks to potentiating action. Those two preservatives are usually used together to enlarge the ranges of antimicrobial activity and to decrease concentrations.

Easy-to-use, formaldehyde-free, and highly stable, Methylisothiazolinone remains functional at up to 70°C, providing potent antimicrobial protection and versatility for many personal care products. Unfortunately, it is a known allergen with many confirmed contact dermatitis and sensitization cases. In addition, it is harmful to aqueous microorganisms and has a bad ecological profile.

Synonyms
Sharomix MT
Salicat MI 10
ALT-MIT

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