Phenylethyl Resorcinol

Functions
Skin whitening agent
Antioxidant
CAS Number(s)
85-27-8
FDA UNII
G37UFG162O

Phenylethyl Resorcinol is a synthetic and stable analog of natural compounds like Pinosylvin (that have free OH groups in specific positions of the aromatic ring) and strong inhibitory activity against the tyrosinase enzyme involved in the melanin production process. It was developed using a screening method when several compounds with similar structures were tested for the specific biological effect, in this case, lessening melanin pigment production or skin whitening. Scientists found the chemical structure and synthesis process of the best candidate is optimized to improve performance and stability and that was Phenylethyl Resorcinol.

It is a highly purified, white crystalline solid compound with a very low odor that can be directly incorporated into the oil phase of skincare preparation with outstanding skin lightening and antioxidant action. Comparative tests with classic skin-lightening agents like Kojic acid, Hydroquinone, Arbutin, and Licorice extract reveal several advantages of Phenylethyl Resorcinol:

  • Cheaper than expensive ingredients like Arbutin, and Licorice extract
  • Better than Kojic acid with sensitizing, hepatotoxic, adverse thyroid effects
  • Safer than Hydroquinone with Cytotoxicity
  • More effective than most classic tyrosinase inhibitors, AHAs, and Vitamin C.

Microscopic examination of human hair follicles also showed lesser melanin quantities after four days of topical application.

The antioxidant action of Phenylethyl Resorcinol has been compared with potent antioxidants like BHT and alpha-Tocopherol (Vitamin E) and showed almost the same quantitive results, which means that this ingredient has potent free radical scavenging ability and protects skin cells from oxidative stress and photoaging.

The safety dossier of Phenylethyl Resorcinol is very well documented. In normal concentrations in formula up to 1%, it is very safe and effective, without adverse effects of similar ingredients.

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