Pentapeptide-4

Functions
Targeting
Firming
Smoothing
Anti-aging
CAS Number(s)
149128-48-3
FDA UNII
69B8BD4H9G

Pentapeptide-4 (former Pentapeptide-3) is a synthetic peptide with the sequence KTTKS (Lys-Thr-Thr-Lys-Ser-OH), a fragment of pro-collagen I. It is known under the trade name Micro-Collagen™. It stimulates the production of dermal matrix components by fibroblasts. However, its ionic nature doesn't allow the delivery of KTTKS peptide through the skin barrier.

Pentapeptide-4's derivatives were more successful thanks to the solution of delivery problems. The first lipo-peptide in the Matrixyl™ range, Palmitoyl Pentapeptide-4 (former Palmitoyl pentapeptide-3), is a superstar ingredient used in many anti-aging products in the last decades. Another derivative with similar properties is Myristoyl Pentapeptide-4 (former Myristoyl Pentapeptide-3), known under the trade name Collasyn 514KS, which is also a successful ingredient.

Thanks to its ability to bind fibroblasts, Pentapeptide-4 found its application unexpectedly - as a targeting peptide in an advanced delivery system, where it conjugated on vehicle capsule guides active ingredients directly target cells. In a delivery system called Trojan®, it is connected with a polymeric capsule consisting of Lactic Acid/Glycolic Acid Copolymer (PLGA) with a covalent bond.

Binding to fibroblasts with "key/lock" type recognition, Pentapeptide-4 significantly enhances the effectiveness of the complex, functionalizing the polymeric capsule, delivering actives directly into the cells, and allowing their concentration to be minimized. It provides targeted, sustained, and managed release of active ingredients in the target cells.
Synonyms
Pentapeptide-3
KTTKS-peptide
Lys-Thr-Thr-Lys-Ser-OH
Micro-Collagen™

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