Ameliox™ is a botanical complex with a wrinkle-smoothing effect similar to Botox. Wrinkles are the result of the weakening of the skin's connective tissue. Weakening, in turn, is the result of structural changes in extracellular matrix proteins, especially collagen fibers. Free glucose molecules can attach to collagen and make changes in its structure; this process called glycation is one of the most significant skin aging factors.

A duo of actives in the Ameliox complex, carnosine, and Milk thistle (Silybum Marianum) fruit extract act synergically, effectively inhibiting glycation. Carnosine is a naturally occurring dipeptide in the human body that rapidly binds to free glucose, preventing its attachment to collagen fibers. Silymarin is a potent polyphenolic antioxidant extracted from milk thistle fruits.

Oxidative stress is one of the promoting factors of glycation, so antioxidant silymarin effectively inhibits (prevents) that destructive process, preserving skin's firmness, suppleness, and elasticity. Ameliox™ is a perfect blend of two skincare actives developed to prevent the stiffening of collagen and the formation of fine lines and wrinkles.

Decrease of wrinkle depth An emulsion with 2% Ameliox was tested in a clinical study with 20 women. The test product was applied twice daily for four weeks on the inner side of the forearm on the forehead and the area with the crow's feet. This complex significantly enhanced hydration levels and skin elasticity, smoothed forearm skin, and decreased wrinkles on the forehead and around the eyes (crow's feet).

Active ingredients (or INCI)

Silybum Marianum Fruit Extract

Ingredient products

Biologique Recherche

Wrinkles are the consequence of the weakening of the connective tissue. Weakening happens because of stiffening and consequent degradation of the structural components, the collagen fibers. A chemical reaction between free sugars and collagen, called glycation, is the cause of stiffening. Glycation is nowadays considered one of the main reasons why living organisms are subjected to aging.

The active substances in Ameliox, carnosine, and silymarin have been shown to effectively inhibit glycation. Carnosine reacts very quickly with free sugars and prevents them from attacking collagen fibers. Silymarin, a polyphenolic substance isolated from milk thistle, is a highly effective antioxidant. Because oxidation is an essential reaction step in the glycation process, silymarin is also an inhibitor of glycation. Ameliox is a powerful combination of two actives to stop the stiffening of collagen fibers, a major reason for the formation of wrinkles and lines.


What are the benefits of Ameliox™?

Ameliox contains Carnosine and Silymarin from the Milk thistle fruit.

  • Carnosine, a naturally-occurring dipeptide in the human body, has antiaging properties by inhibiting the glycation reaction in the skin.
  • Silymarin is a powerful antioxidant, and another powerful glycation inhibitor.

A clinical study showed a significant decrease in wrinkle depth. An emulsion with 2% Ameliox™ was tested in a clinical study with 20 women. The test product was applied twice daily for four weeks on the inner side of the forearm and the forehead, and the area with crow's feet.

Ameliox significantly improved the forearm skin's hydration, firmness, and smoothness (data not shown) and reduced wrinkle depth on the forehead and around the eyes (crow's feet).