Argirelox is a complex that combines the power of two revolutionary peptides fighting against expression lines and deep wrinkles by relaxing mimic muscles and lessening contractions.

Argireline (Acetyl Hexapeptide-8) reduces the depth of expression wrinkles, acting as a safer alternative to Botulinum Toxin A. Applied topically, it targets the same wrinkle formation mechanism (blocking nerve and muscle connection), but in a very different way (destabilizes the SNARE complex a protein combination required for muscle contraction).

Leuphasyl (Pentapeptide-18) offers a new, parallel, complementary way for expression wrinkles reduction. It also blocks the neuro-muscular connection, preventing neurotransmitters release and signal transfer from the nerve to the muscle. In addition, the combination of Leuphasyl with other anti-wrinkle peptides such as Argireline provides a synergistic additive effect proven in vitro and in vivo studies.

The combination of both peptides ARGIRELOX™ offers an integral treatment for expression wrinkles: reduced are the depth of wrinkles on the face caused by the contraction of muscles of facial expression, particularly in the forehead and eye area.

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How does Argirelox work?

Argirelox is a high-quality anti-wrinkle peptide system that has been used in many high-end skincare formulas. It contains two peptides with similar effects, but action mechanisms are different.

Acetyl hexapeptide-8 (Argireline) can locally block the nerve transmission of muscle contraction information, affect the nerve-muscle conduction, relax the facial muscles, and smooth the dynamic, static, and fine lines. It effectively smooths the facial lines and improves the relaxation of wrinkles.
Acetyl hexapeptide-8 has a similar effect to botulinum toxin. However, because of a series of side effects of botulinum toxin, including pain caused by a puncture, erythema, edema, and blepharoptosis caused by toxin diffusion, facial asymmetry, and difficulty in speaking, it is urgent to find new substitutes, and Acetylhexapeptide-8 emerges from a series of compounds. Its efficacy is comparable to botulinum toxin A, but it avoids the disadvantages of being injected and used at a high cost.

Action mechanism of Argirelox™

Muscle contraction occurs when the muscle receives neurotransmitters from the nerve. Neurotransmitters are synthesized in the cell body of neurons and stored in synaptic vesicles. When stimulated by the outside world, a kind of extracellular secretion (called SNARE protein combination) that is calcium-dependent causes synaptic vesicles to release neurotransmitters, which reach the postsynaptic membrane through the synaptic gap and interact with corresponding receptors. The snare comprises three proteins: vamp, syntaxin, and SNAP-25.
The structure of Acetyl Hexapeptide-8 is similar to SNAP-25, which competes with SNAP-25 to occupy the position of SNAP-25 in the SNARE complex, thus inhibiting the formation of the snare, making muscles unable to receive neurotransmitters, limiting muscle contraction effectively, and finally preventing skin wrinkles. In addition, excessive release of catecholamine can also cause wrinkles. Acetyl Hexapeptide-8 can inhibit the release of catecholamine. Therefore, it is a kind of botulinum toxin mechanism, by inhibiting the synthesis of SNARE receptor, inhibiting the excessive release of catecholamine and acetylcholine in the skin, locally blocking the nerve transmission of muscle contraction information, affecting the nerve conduction of the skin capsule, relaxing the facial muscles, and achieving the purpose of smoothing the dynamic, static and fine lines. However, it is different from the anesthesia mechanism of botulinum toxin A, allowing muscles to move and express naturally, so it has no other side effects.

Pentapeptide-18 (Leuphasyl) mimics natural neuropeptides like Enkephalin naturally occurring peptides that bind opioid receptors. Leuphasyl closes Ca2+ channels and opens K+ channels, preventing neurotransmitters release across the nerve-muscle synapse and relaxing mimic mascles. So, those two peptides have different action mechanisms but exhibit similar effects, working synergically to deliver better results.