Acetyl sh-Heptapeptide-1

Functions
Antioxidant
Detoxification
Photoprotective
Skin conditioning
CAS Number(s)
1395088-14-8

Acetyl sh-Heptapeptide-1 is a modified synthetic recombinant peptide with sequence Ac-Asp-Glu-Glu-Thr-Gly-Glu-Phe, that repeats a part of a sequence of Nrf2 protein that acts as a self-protective master switch that prevents extrinsic and chronological aging. It is known under the trade name PerfectionPeptide P7.

Nrf2 is Nuclear factor erythroid 2-related factor 2, also known as nuclear factor erythroid-derived 2-like 2, is a transcription factor located in the cytosol that fights against aging by:

  • Increasing synthesis of cell-protective enzymes that accelerate the breakdown of free radicals and toxins
  • Recycling and replenishment of cellular antioxidants like glutathione.

With aging Nrf2's self-protective activity declines and it becomes unable to cope with harmful chemical species. Nrf2's activity is regulated (suppressed) by Keap1 protein (Kelch-like ECH-associated protein 1) which forms a Nrf2/Keap1 complex. Acetyl sh-Heptapeptide-1 contains the ETGE sequence of Nrf2 and binds to Keap1 preventing complex formation, activating (freeing up) Nrf2, and inducing the production of cell-protecting enzymes.

Incorporated in skin care applications, Acetyl sh-Heptapeptide-1 effectively protects the skin from UV- and oxidative stress-induced DNA damage. It also helps protect Langerhans cells from UV damage, protecting the skin's immune function from depletion caused by irradiation. In short, activating skin's self-protective ability, it combats both environmental and chronological aging, enhancing skin's antioxidant capacity, protecting DNA from oxidation, and neutralizing free radicals.
Synonyms
PerfectionPeptide P7

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