X50® Hyalufiller

X50® Hyalufiller is a peptide-based complex ingredient with an advanced mechanism of delivery (Cosmetic Drone™) and targeted release of biologically active components. The complex structure consists of three parts:

  • Polymer capsule (Lactic Acid/Glycolic Acid Copolymer with Polyvinyl Alcohol) that protects the active ingredient
  • An externally anchored target peptide (Heptapeptide-15 palmitate) that binds to skin fibroblasts by a key/lock mechanism, providing targeted delivery of active ingredients and mimicking natural growth factors
  • An active peptide (Palmitoyl Tetrapeptide-50) that boosts hyaluronic acid and other GAGs (glycosaminoglycans) production by increasing the Hyaluronan synthase 2 (HAS2) enzyme synthesis.

Filling wrinkles with dual action, X50® Hyalufiller improves elastin production and enhances skin's moisture-binding ability, exposing a smoother, supple, and rejuvenated appearance. It provides additional volume, elasticity, and density. Skincare preparations with X50® Hyalufiller can extend and prolong the outcome of hyaluronic acid injections.

X50® Hyalufiller is produced in two forms liquid and powder with different compositions:

Powder Form
Inci Name: Lactic Acid/Glycolic Acid Copolymer; Polyvinyl Alcohol, Palmitoyl Tetrapeptide-50 (Encapsulated Peptide), Heptapeptide-15 palmitate (Target Peptide)

Liquid Suspension Form
Inci Name: Water (Aqua), Xanthan Gum, Palmitoyl Tetrapeptide-50 (Encapsulated Peptide), Lactic Acid, Glycolic Acid, Polyvinyl Alcohol, Heptapeptide-15 palmitate (Target Peptide)
Additives: Phenoxyethanol, Caprylyl Glycol, Glycerin, Glyceryl Caprylate, Phenylpropanol.


Active ingredients (or INCI)


What are the benefits of X50® Hyalufiller for the skin?

Four beneficial actions include:

  • Boosts the synthesis of hyaluronic acid and elastin
  • Induces the expression of mRNA that encodes HAS2
  • Protects cells from dehydration
  • May help to prolong the effect of HA injectables