Matrixyl® was initially a single cosmetic ingredient Palmitoyl pentapeptide-4 (INCI: Palmitoyl pentapeptide-3 before 2006) a matrikine lipopeptide developed by Sederma. It consists of 5 amino acids length peptide with significant anti-wrinkle activity and a lipophile part - 16-carbon length chain providing improving adsorption through the skin's lipidic barrier. The term matrikine was martikines introduced by Pr. Maquart and his colleagues from France in 1999, which means short-chain peptides derived from ECM (extracellular matrix) proteins like collagen or elastin with biologically active properties such as fibroblast stimulation, increasing the production of ECM components or inhibiting their degradation processes. Playing an important role in the regulation of skin cell activity, martikines (ECM protein fragments) speed up wound healing, recovery, and renewal, providing much-anticipated effects for cosmetic formulations.

Later, encouraged by the success, Sederma developed newer ingredient complexes based on martikines and united them in a range called Matrixyl Inside® that includes an iconic Matrixyl® 3000 launched in 2003 that frequently appears in many modern formulations and novel Matrixyl® Morphomics™ and Matrixyl™ Synthe’6™ with different mechanisms of action and different efficacy.

N-Prolyl Palmitoyl Tripeptide-56 Acetate is a new, innovative, and award-winning peptide that boosts collagen and fibronectin production, improving extracellular matrix structure, fibers organization, and skin density.

Naturally occurring peptides in the skin perform critical roles in skin maintenance and repair, and there is growing interest in harnessing these effects for therapeutic and cosmetic use.

Matrixyl 3000 combines two peptides that help to improve the cellular health of the skin cells, specifically the skin’s extracellular matrix.
Matrixyl™ synthe’6™ is a potent peptide that boosts six skin-rebuilding essentials: macromolecules - proteins and glycosaminoglycans.

Pal-KT (Palmitoyl Dipeptide-7) is the shortest matrikine lipo-peptide with anti-aging action that repeats the part of the sequence (palmitoyl-lysine-threonine) of the famous Matrixyl™ pentapeptide (Pal-KTTKS) and exhibits similar properties, boosting extracellular matrix (ECM) components producti

Palmitoyl Tripeptide-38 also known as Pal-KMO2K is a matrikine-mimetic peptide, that stimulates hyaluronic acid and collagen production.

Several studies in the 90s showed that on the cellular level stretch marks formation process starts with endogenous glucocorticoid (corticosteroids) secretion under influence of stress or hormonal changes during puberty or pregnancy.