Several studies in the 90s showed that on the cellular level stretch marks formation process starts with endogenous glucocorticoid (corticosteroids) secretion under influence of stress or hormonal changes during puberty or pregnancy. Under the action of corticosteroids, the growth of both keratinocytes and fibroblasts is blocked, as is their synthesis of collagens I and III: 90% less than normal skin. In addition, fibronectin synthesis is reduced: 93% less than in normal skin.
Subsequently, at the margins of the forming stretch mark and in the direction of the future longitudinal progression degranulating must cells release proteolytic enzymes trypsin and chymotrypsin. Those enzymes break down ECM (extracellular matrix) proteins, particularly collagen, and elastin. Macrophages invade the lesion zone to clean up the fragmented matrix but also complete the elastolytic process.
Regestril™ is a complex ingredient of mixed origin including botanicals and peptides combined to fight against stretch marks in a complementary way. The complex has three simultaneous actions:
- The green bean (Phaseolus Lunatus seeds) extract contains a protein that inhibits trypsin and chymotrypsin. The protein's three-dimensional structure has 2 trypsin and chymotrypsin recognition sites thus conferring an inhibitory effect on that enzymes.
- Rutin is a powerful antioxidant that has a stabilizing effect on mast cells and the anti-elastase (elastin preserving) properties,
- The peptides duo that already demonstrated its efficacy in a superstar ingredient Matrixyl™ 3000 for reconstitution of the extracellular matrix components including collagen and elastin.
In summary, the peptides, Pal-GQPR and Pal-GHK, in Regestril™, through their complementary effects on fibroblasts, contribute to the generation of the extracellular matrix consisting of collagens I and IV and fibronectin. In addition to the stimulation of proteoglycan synthesis, rutin exerts protective effects while Phaseolus extract antagonizes the proteolytic enzymes, trypsin, chymotrypsin, and elastase, released by mast cells and macrophages (inflammatory leukocytes).