O.D.A. White™ is a skin-brightening ingredient from the "heart" of the melanocyte with a new mechanism of action. Sederma developed this ingredient to treat skin pigmentation disorders such as freckles, melasma, hyperpigmentation, and the general dark color of ethnic skin.
Many skin-lightening ingredients (or claimed as such) are essentially conceived as an inhibitor of this tyrosinase. O.D.A.white™ appeared as a good candidate for effecting melanin synthesis decrease via another, even further upstream, mechanism. Sederma showed that O.D.A.white™ does not mediate melanin synthesis reduction by direct inhibition of
tyrosinase but can inhibit the whole melanin synthesis pathway from the melanocyte nucleus by targeting the tyrosinase gene via the PPARγ complex.
In vitro studies showed, that in the presence of O.D.A.white™, mRNA tyrosinase and tyrosinase quantities decrease by 50%, producing a decrease of the pigmentation by 44%.
Active ingredients (or INCI)
How effective is O.D.A. White™ for skin-brightening?
A clinical study was carried out on a total of 21 Chinese panelists, with twice daily random applications of 1% O.D.A.white™ against arbutin on the forearm for 8 weeks followed by a 4-week regression period.
It has shown spectacular skin-brightening effects. The melanin synthesis begins to decrease after application, reaches -22% after 8 weeks for the majority (76%) of the panel, and leads to an increase of the skin clarity up to 28%. This effect is reversible.
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