SensAmone P5


SensAmone P5 is a peptide-based complex ingredient inspired by nature under the sea. It is an active soothing pentapeptide (Pentapeptide-59) incorporated into a soft sphere support system based on shea butter and lecithin to ensure the stability and bioavailability of ingredients in skin care preparations. SensAmone P5 is a smart solution to relieve sensitive and irritated skin.


In the never-ending search for exciting new sources of active ingredients, much of the attention these days has shifted to marine-derived ingredients. This makes new discoveries that propose beneficial effects for our skin, highly interesting for the cosmetics industry.

One of the fascinating inhabitants of the sea is the sea anemone, known to many as the home of the clown fish. A lesser-known fact is that because the sea anemone is soft and vulnerable, it produces venom to protect itself from predators and also to immobilize prey. One of the components of a sea anemone Heteractis crispa venom is an APHC1 protein. It can effectively block the pain receptor TRPV1 in dermal cells which makes it an interesting study object to find a remedy for sensitive skin.


TRPV1 is the pain receptor that is overactive in sensitive skin. The TRPV1 receptor is responsible for transmitting the sensation of pain when in contact with heat, chemicals, and acids. It is present in our skin, as this is the first barrier that encounters environmental stress. While receptor activity is important in protecting us from harm, such as reacting to pain and withdrawing our hands from touching a hot surface, overactivity can be harmful as well.

Sensitive skin is especially characterized by a hyper-reactive pain receptor that manifests itself as skin that feels very tight, itchy, and even burning - even if there are no harmful influences on the skin. In addition to being responsible for skin discomfort, the TRPV1 receptor is also involved in skin aging.

In photoaged skin, TRPV1 is often overexpressed. Furthermore, the constant activation of TRPV1, for example by thermal and infrared radiation, leads to the upregulation of enzymes that destroy collagen in the skin, which can lead to premature aging of the skin. Therefore, the solution is to reduce the activation of TRPV1 in sensitive skin to normal levels to strengthen the tolerance level and reduce the uncomfortable feeling of the skin.

Pentapeptide-59 is a synthetic peptide that mimics sea anemone Heteractis Crispa venom that inhibits TRPV1 pain receptors up to 80%. It is more effective than natural venom and soothes skin and prevents premature aging.