Tranexamoyl Dipeptide-22

Functions
Skin whitening agent
Hair bleaching

Tranexamoyl Dipeptide-22 is a synthetic tripeptide with sequence Txa-Val-Ser (Tranexamil-VS; TXA-VS) that exhibits skin whitening activity. It inhibits the activity of tyrosinase, one of the critical enzymes involved in melanin production.

In addition, Tranexamoyl Dipeptide-22 inhibits the expression of MITF (microphthalmia-associated transcription factor) responsible for the differentiation and proliferation of melanocytes (melanin-producing cells). Thanks to its dual action mechanism, it leaves a significant skin-whitening effect, fighting against hyperpigmentation, melasma, and dark spots.

Tranexamoyl Dipeptide-22 is a derivative of Tranexamic acid used as a skin-whitening agent. Its modification enhances stability in formulations and improves effectivity. Thanks to its small molecule size, it exhibits good skin permeability and a high penetration rate.

Combined with other skin-whitening agents, especially with Tranexamic acid and similar Tranexamoyl- and Nicotinyl-peptides, Tranexamoyl Dipeptide-22 potentiates their action and improves the entire effectivity of formulation. Cytotoxicity tests showed that it is a safe ingredient for skincare applications.
Synonyms
TXA-VS
Tranexamil-VS

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