Uplevity™

Functions
Firming
Anti-aging

Counteracts the force of gravity

Uplevity™ is a peptide invented to fight the undesired effects of a lack of skin firmness and cohesion by enhancing the natural elements that help to maintain collagen levels and elastin fibers correctly assembled, and facilitating the union between cells and the ECM (extracellular matrix). This ingredient not only proved to activate the FBLN5 and LOXL1 promoters but also increased both protein levels in vitro, that as we previously mentioned are necessary elements for a correct assembly of elastin fibers.

Moreover, it highly induced the synthesis of elastin. It also showed to upregulate genes related to FAs and collagen synthesis, highly inducing the synthesis of type I collagen as well. In vivo, the peptide showed to clearly reduce specific parameters linked to skin flaccidity and dermal disorganization, which translates into a better inner restructure of the dermis and skin cohesion.

UPLEVITY™ is an ideal ingredient to improve skin firmness by enhancing the natural elements that manage to maintain these properties in the skin, including elastin and collagen. Thus, it can be incorporated into firming and anti-aging formulations for both facial and body care, where skin cohesion and resilience want to be increased to minimize sagginess and flaccidity. In addition, it would be also useful to add slimming formulations to avoid flaccidity after losing weight.

Ingredients

F.A.Q.

What are the benefits of Uplevity™?

Acetyl Tetrapeptide-2 is an innovative tetrapeptide to increase skin firmness, avoiding sagginess and flaccidity.

Additional benefits include:

  • Raises the activity of FBLN5 and LOXL1 promoters by 1.2-fold and 1.3-fold respectively (at 1 mg/mL), promoting the expression of these key elements and the correct assembly of elastin fibers.
  • Augmented FBLN5 and LOXL1 protein levels by 2.3-fold and 1.7-fold respectively, which help elastin fibers to be assembled accurately.
  • Upregulates the expression of genes involved in collagen synthesis and FAs (talin and zyxin among others), all of them beneficial elements that improve skin cohesion.
  • Provides a statistically significant induction of elastin synthesis (21.7%), a protein directly linked to skin elasticity and recoil.
  • Increases type I collagen synthesis by 47.3% (statistically significant value), helping to improve skin firmness.
  • Improves skin cohesion, as in vivo (at 2%) it reduced the indentation (-9.5%) and the area (-23.2%) parameters, which are directly linked to lower firmness, and the fragmentation rate of the upper and deeper reticulum (-39.6 and -37.9% respectively), whose decreases are associated to an improvement of skin restructuration.

Related ingredients

Acetyl Dipeptide-1 Cetyl ester
Acetyl Dipeptide-1 Cetyl ester
This lipopeptide exhibits good stimulating results on elastin production. As a result, Acetyl Dipeptide-1 Cetyl ester fights against cutaneous sagging and decreases the visible effects of gravity on the skin.
Acetyl Heptapeptide-9
Acetyl Heptapeptide-9 mimics the TGFβ. Acetyl Heptapeptide-9 effects on fibroblasts, stimulating collagen, elastin, and other components of ECM production.
Acetyl Tetrapeptide-5
Acetyl Tetrapeptide-5
Acetyl Tetrapeptide-5 is a fantastic, super effective, naturally derived tetrapeptide that helps reduce the look of puffy eye bags and dark circles under the eyes and helps prevent them from reappearing.
Acmella Oleracea Extract
Acmella Oleracea Extract
Acmella Oleracea is an exotic plant, also known as Paracress. In the Indian Ocean region, it is called "Mafane". Reduces facial muscle micro-contractions, smoothes and reduces lines and wrinkles.
Acnacidol™ BG
Acnacidol™ BG
Acnacidol™ BG is a clinically tested complex that contains Queen bee acid (10-HDA or 10-Hydroxydecanoic Acid found in Royal Jelly that controls and reduces sebum and the appearance of acne.
Adenosine 5 Triphosphate (ATP)
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Naturally existing in our bodies as part of the molecule adenosine triphosphate (ATP), responsible for transporting energy for numerous cellular and muscular functions in our body
Alistin®
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Alistin® (Decarboxy Carnosine) is a synthetic antiaging pseudodipeptide with high stability and resistance to enzymatic hydrolysis, that cell membranes oxidative stress and dermal fiber from cross-linking.
AquaCacteen™
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Ascorbyl Tetraisopalmitate
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Like other forms of Vitamin C, Ascorbyl Tetraisopalmitate helps prevent cellular aging by inhibiting the cross-linking of collagen, oxidation of proteins, and lipid peroxidation.
Bakuchiol
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Barley (Hordeum Vulgare) extract
Barley (Hordeum Vulgare) extract
Barley contains a large variety of vitamins, including beta carotene (provitamin A), thiamine (vitamin B1), riboflavin (B2), pyridoxine (B6), cobalamins (B12), pantothenic acid (B5), and folic acid (B₉), which all play an essential role in dermal cells metabolism and necessary for normal functioning.
Biopeptide EL™
Biopeptide EL™
Biopeptide EL™ is a peptide-based complex ingredient for skin firmness and tone improvement. Palmitoyl Hexapeptide-12 is a synthetic lipo-peptide, a derivative of VGVAPG-peptide with the sequence Val-Gly-Val-Ala-Pro-Gly which is a fragment of the natural elastin.