Palmitoyl Oligopeptide-78 is a synthetic biomimetic lipo-peptide that stimulates keratin production by keratinocytes, enhancing epidermis thickness, lessening transdermal moisture loss, and enhancing the barrier function of the skin.
Skin conditioning
In skin care, conditioning is everywhere. Consumers have always wanted their skin moisturized, nourished, restored, and protected. Each of these benefits results from the activity we call conditioning.
Here are some of the most intriguing products for providing conditioning effects. They have performance properties offering "extraordinary" conditioning for the skin.
These are specialty ingredients that create memorable, distinctive features in skincare products – the kind of features that will help offerings stand out in the minds of customers.
From phospholipids to quaternaries, the products in the line are based on exceptionally creative chemistry, making them ideal ingredients for today's personal care products. Features such as mildness, substantivity, high performance, and multifunctionality are common in modern skin conditioners.Palmitoyl sh-Octapeptide-24 Amide is a lipo-peptide derived from palmitic acid and a synthetic analog of a human peptide that inhibits the expression of genes responsible for tyrosinase enzyme production. The Lipophile part (palmitic) provides stability and improves delivery.
Palmitoyl sh-Tetrapeptide-2 Amide is a lipo-peptide that inhibits interleukin-1R, an inflammatory cytokine receptor, soothing skin irritation and acting as an anti-inflammatory agent. It is known under the trade name Ilonerin™.
Palmitoyl sh-Tripeptide-1 Amide is a low molecular weight synthetic recombinant lipo-peptide derived from FGF-1 (fibroblast growth factor -1) that is involved in various cellular processes, including angiogenesis, keratinocyte organization, and wound healing.
Palmitoyl sh-Tripeptide-2 Amide is a low molecular weight lipo-peptide derived from Tumor Necrosis Factor Receptor (TNFR) that inhibits TNF-α ( tumor-necrosis factor-α). It is known under the trade name Tenefrin™.
Palmitoyl sh-Tripeptide-3 Amide is a low molecular weight lipo-peptide derived from Epidermal Growth Factor (EGF) that stimulates cell growth, proliferation, and differentiation by binding to its receptor EGFR. It is also known under the trade name Synepin™.
Palmitoyl sh-Tripeptide-4 Amide is a low molecular weight lipo-peptide (316.3 Da) derived from CD99, an anti-inflammatory molecule that is expressed in all human cells. It is also known under the trade name Binterin™.
Palmitoyl Sh-Tripeptide-5 Norisoleucyl Sh-Nonapeptide-1 is a lipo-peptide that acts as an antagonist of
Palmitoyl Tetrapeptide-7 (also known as Rigin™) is a lipopeptide from Sederma designed to mimic DHEA activity and restore cytokine balance to mature skin.
Palmitoyl Tetrapeptide-72 Amide is a synthetic lipo-peptide with sequence Pal-His-Tyr-Arg-Ala-NH2 that boosts expression and production of Mohawk, a homeodomain protein abundantly expressed in the young skin and actively involved in the regeneration of EMC components and connective tis
Palmitoyl Tripeptide-1 stimulates fibroblasts and enhances the production of collagen and GAGs, smoothing fine lines and deep wrinkles and improving the water-binding ability and elasticity of the skin.
Palmitoyl tripeptide-28 is a peptide ingredient based on TGF-β (Transforming growth factor beta) that mimics cytokine action by binding with specific receptors (TGF beta receptor 2) on fibroblast membrane, stimulating the production of extracellular matrix (ECM) components.
Palmitoyl Tripeptide-36 is a synthetic lipo-peptide known under the trade name DermaPep™ M330 that exhibits anti-microbial activity. It inhibits the growth of Staphylococcus aureus and other bacteria, and fungi. Peptide sequence is Palmitoyl-Lys-Met(O2)-Lys-OH.
Palmitoyl Tripeptide-37 is a synthetic lipo-peptide with sequence Pal-KFK (Palmitoyl-Lys-Phe-Lys) that leaves thrombospondin-like action. It is an analog of Lipospondin. It is an ester of palmitic acid and Tripeptide-37 (KFK peptide) with an active Thrombospondin domain sequence.
Palmitoyl Tripeptide-38 also known as Pal-KMO2K is a matrikine-mimetic peptide, that stimulates hyaluronic acid and collagen production.
Palmitoyl Tripeptide-53 Amide (known under the trade name Winhibin™) is a low molecular-weight tripeptide derived from Sfrp5 (Secreted frizzled protein5) and known as a modulator adipokine of WNT-signaling.
Panthenol is a provitamin of Pantothenic acid (vitamin B5), part of the B-complex group, is present in all living cells and is a constituent of coenzyme A. The critical function of this coenzyme is to act as a carrier in acetylation reactions (Krebs cycle).
Vitamin B5 (Pantothenic acid) is a precursor of the coenzymes involved in more than 100 different metabolic pathways including energy metabolism of carbohydrates, proteins, and lipids, and the synthesis of lipids, neurotransmitters, steroid hormones, porphyrins, and hemoglobin.
Papain is produced from the milky latex of all papaya parts but especially in the green, unripe fruits by scarification of the skin of the fruit and inducing latex flow.
Papain, one of the active enzymes in papaya, has antimicrobial properties. Papaya can help reduce edema, may discourage clotting, and promotes wound healing, and the active enzymes also mildly exfoliate the skin.
Paraffin is a class of mineral waxes obtained from the petroleum refining process. It is a white-to-yellowish solid containing straight-chain saturated hydrocarbons, which are predominant in functionality. Based on melting point, paraffin has five different grades, ranging from 120-155ºC.
Rich in vitamin C, provitamin V and chlorophyll, parsley is thought to have antimicrobial, antiseptic, and astringent properties that soothe the skin.
Passiflora Edulis Seed Oils PEG-8 Esters is a hydro-dispersible emollient based on natural oil from the passion fruit. It is also known under the trade name Hydramazon Passiflora.
Passionflower (Passiflora Incarnata) is reportedly an aphrodisiac, although the name itself is not derived from that reputation. It was named during the 17th century by Jesuit priests and explorers from Spain and Italy who professed to see symbols of the crucifixion in the plant's blossoms.
Passionflower (Passiflora Incarnata) fruit is native to Jamaica and South America. It was believed by the Aztec Indians to have medicinal and erotic powers.
PCA Dimethicone is an isomer of the natural moisturizing factor "PCA" covalently bonded to a silicone backbone. It is designed for easy addition to leave-on and rinse-off conditioning and cleansing products.
PEG-10 Dimethicone is an excellent silicone-based surfactant for all classes of personal care formulas, particularly well suited in skin care. Specially designed for Silicone-in-Water emulsions, it is more hydrophobic and film-forming than PEG-11 Methyl Ether Dimethicone.
PEG-11 Methyl Ether Dimethicone is an excellent silicone-based surfactant for all classes of personal care formulas, particularly well suited in skin care. Specially designed for mixed oil-in-water emulsions, it is more hydrophilic and less film-forming than PEG-10 Dimethicone.
PEG-12 Dimethicone is a copolymer of polydimethylsiloxane and polyoxyalkylene ether. This combination gives this type of ingredient unique properties. It is clear to hazy and colorless to straw liquid.
PEG-8 Dimethicone is a nonionic silicone wax, a water-soluble dimethicone polyethyleneglycol block copolymer. It is a white wax with a melting point of 36 – 49°C. Its former designation was Dimethicone Copolyol.