sh-Oligopeptide-1 is a synthetic analog of human polypeptide EGF (Epidermal Growth Factor) that contains 53 amino acids. EGF is found in varying concentrations in milk, saliva, urine, plasma, and also in most other body fluids.
Peptides
There are numerous examples in physiology of peptide regulatory elements that play integral roles in basic homeostatic mechanisms such as injury-repair responses and other stimulus-response actions. Among these are well-known neuropeptides (e.g., bradykinins, endorphins); metabolism and fat storage regulators (e.g., neuropeptide Y, leptin, insulin); tanning and skin pigmentation-related peptides (e.g., α-MSH, ACTH, Agouti), and peptides involved in wound healing (e.g., FGF).
This large group of innovative cosmeceutical ingredients triumphed in the world of skincare products during the last two decades. Peptides are chains of amino acids that are attached in a specific order. Amino acids are naturally occurring in the body and are vital to everyday living processes. Peptides can be made up of 2 or more amino acids that can stimulate different responses within the body. As a result, peptides serve as tiny messengers that can be sent to kick the skin into gear and make it look better.
Peptides are leading a beauty revolution due to their excellent multi-functional properties; formularies are scrambling to access the latest advances in cosmetic peptide technology. In addition, their "Botox-like" performance, activation of collagen and elastin production, and skin-lightening effect make them very efficient against coarse wrinkles and hyperpigmentation of the skin.
sh-Oligopeptide-2 is a synthetic single chain (7.6 kDa) polypeptide hormone structurally similar to proinsulin, which is an Insulin-like Growth Factor (IGF-1) naturally synthesized in the liver and fibroblast cells.
sh-Oligopeptide-4 is a synthetic recombinant Thymosin-β4 peptide that helps strengthen hair while stimulating hair follicles to produce healthier hair.
sh-Oligopeptide-5 is an N-terminal fragment of human AIMP1 (ARS-interacting multi-functional protein 1).
sh-Oligopeptide-78 is a synthetic recombinant 20 amino acid long, biomimetic peptide, with a sequence corresponding to a part Type II Keratin, which repeats several times in that structural protein. It is known under the trade name K18Peptide™.
sh-Oligopeptide-85 is a synthetic recombinant peptide, an analog of human Dyskerin involved in stabilizing to RNA molecules and ribosome biogenesis regulation.
sh-Pentapeptide-1 (former INCI name: Pentapeptide-1) is a synthetic recombinant peptide derived from thymopoietin, a human hormone with immunomodulating properties.
sh-Pentapeptide-5 is a synthetic recombinant peptide that mimics endorphin action and leaves a Botox-like effect. This opioid peptide effectively reduces the appearance of expression lines and deep wrinkles exposing smoother, younger-looking, and healthy skin.
sh-Pentapeptide-6 Trifluoroacetate synthetic recombinant peptide that boosts stratifin protein production improving bio-messaging between skin layers (epidermal-dermal "cross-talk") and leading to dermal remodeling and wrinkle repair.
sh-Polypeptide-1 is a single-chain synthetic peptide (molecular weight 17.25 kDa) hormone bFGF (basic Fibroblast Growth Factor) that regulates skin's renewal promotional subtraction It is also an essential constituent for maintaining the best condition of the body as this is concerned with restor
sh-Polypeptide-10 is a synthetic recombinant single-chain peptide, an analog of human Fibroblast Growth Factor 10 (FGF10) that is involved in normal skin growth, regeneration, and wound repair.
sh-Polypeptide-11 (former rh-Oligopeptide-13; rh-Polypeptide-11) is known under the trade name CG-aFGF, a single-chain synthetic recombinant
sh-Polypeptide-12 is a synthetic recombinant single-chain peptide, an analog of human Interleukin 4 (IL-4) that plays the role of an anti-histamine or immune-suppressor agent to reduce scratching by inhibiting the autoimmune response.
sh-Polypeptide-121 is a synthetic single-chain recombinant peptide derived from human collagen type 21 (also called collagen alpha-1 and encoded by the COL21A1 gene). It is known under the trade name HumaColl™21.
sh-Polypeptide-19 (former rh-Oligopeptide-3) is a synthetic single-chain recombinant peptide, an analog of human TGF-α (Transforming Growth Factor-α). It boosts new dermal cell generation improving skin tone that brimming with vitality & energy.
sh-Polypeptide-2 is a synthetic recombinant analog of human Thioredoxin (TRX) that stimulates dermal cell growth and proliferation and protects them from oxidative stress. Thioredoxin is a natural cytoprotector peptide present in all human cells.
sh-Polypeptide-22 is a synthetic recombinant human transforming growth factor beta 1 (TGFβ-1) analog peptide composed of 113 amino acids.
sh-Polypeptide-28 is a synthetic recombinant human prolactin hormone analog peptide composed of 199 amino acids. Applied topically, prolactin leaves multiple beneficial effects on the skin including:
sh-Polypeptide-3 (former rh-Oligopeptide-5) is a single-chain synthetic recombinant peptide, an analog of human KGF (Keratinocyte Growth Factor). KGF was first described in 1989 as a human growth factor that stimulated epithelial cell proliferation.
sh-Polypeptide-31 is a synthetic recombinant peptide that mimics human Insulin-like Growth Factor-2 (IGF-2). The old INCI name was rh-Polypeptide-31 (rh- prefix means recombinant human).
sh-Polypeptide-4 is a synthetic analog of human SCF (Stem cell factor), a peptide of 164 amino acids. It is a cytokine that controls the survival, growth, and differentiation of hematopoietic stem cells.
sh-Polypeptide-40 is a synthetic recombinant human placental lactogen (hPL) analog peptide composed of 192 amino acids. hPL is also known as human chorionic somatomammotropin (hCS) or human chorionic somatotropin.
sh-Polypeptide-5 is a synthetic recombinant peptide, an analog of human TGFβ3 (Transforming Growth Factor β3). It regulates the proliferation, growth, and differentiation of skin cells as a powerful multifunctional cytokine and keeps the skin young by converting old cells into new ones.
sh-Polypeptide-6 is a synthetic recombinant single-chain peptide, an analog of human Interleukin 10 (IL-10). Interleukin 10 is an anti-inflammatory cytokine that regulates the immune response and antibody production.
sh-Polypeptide-64 is a synthetic recombinant peptide derived from the human Aquaporin-1 (AQP-1) protein that promotes the transport of water biological membranes. AQP-1 is normally expressed in dermal cells, including keratinocytes, melanocytes, fibroblasts, and vascular endothelial cells.
sh-Polypeptide-7 is a synthetic part of human growth hormone (hGH) also called Somatotropin. It repeats 20 amino acid sequences from 191 of hGH and mimics its action, stimulating the growth, reproduction, and regeneration of skin cells.
sh-Polypeptide-71 (former sh-Polypeptide-65) is a synthetic recombinant human vasoactive intestinal peptide or VIP composed of 28 amino acids. This biologically active peptide controls vasodilatation in skin tissue, soothes inflammation, and improves angiogenesis.
sh-Polypeptide-8 is a synthetic single-chain recombinant analog of human PDGF (Platelet-Derived Growth Factor) that is involved in normal skin growth, healing, and wound repair.
sh-Polypeptide-9 is a synthetic recombinant analog of human VEGF (Vascular Endothelial Growth Factor). It enhances the division and migration of cytokine by increasing the permeation of serum protein in the capillary vessels.
sh-Polypeptide-93 is a synthetic recombinant human connective tissue growth factor (CTGF) analog peptide composed of 324 amino acids. It mimics an Insulin-like Growth Factor (IGF)-binding domain of CTGF regulating the expression of genes responsible for collagen production in fibroblasts.