Hexacarboxymethyl Dipeptide-12 is a peptide derivative that acts as a direct activator of Sirtuin1 (SIRT1). SIRT1 is an NAD+-dependent deacetylase enzyme that regulates cellular metabolism, survival, and lifespan. It deacetylates the target protein FoxO1, initiating cell autophagy.
Peptides
There are numerous examples in physiology of peptide regulatory elements that play integral roles in basic homeostatic mechanisms such as injury-repair responses and other stimulus-response actions. Among these are well-known neuropeptides (e.g., bradykinins, endorphins); metabolism and fat storage regulators (e.g., neuropeptide Y, leptin, insulin); tanning and skin pigmentation-related peptides (e.g., α-MSH, ACTH, Agouti), and peptides involved in wound healing (e.g., FGF).
This large group of innovative cosmeceutical ingredients triumphed in the world of skincare products during the last two decades. Peptides are chains of amino acids that are attached in a specific order. Amino acids are naturally occurring in the body and are vital to everyday living processes. Peptides can be made up of 2 or more amino acids that can stimulate different responses within the body. As a result, peptides serve as tiny messengers that can be sent to kick the skin into gear and make it look better.
Peptides are leading a beauty revolution due to their excellent multi-functional properties; formularies are scrambling to access the latest advances in cosmetic peptide technology. In addition, their "Botox-like" performance, activation of collagen and elastin production, and skin-lightening effect make them very efficient against coarse wrinkles and hyperpigmentation of the skin.
Hexanoyl Dipeptide-3 Norleucine Acetate is a synthetic biomimetic tripeptide that boosts the natural desquamation process of the skin. It occupies the binding site of a protein (desmosome) responsible for epidermal cell adherence, acting as a "smart" exfoliating agent.
Hexapeptide-10 is a synthetic peptide (known under the trade name Serilesine®) that repeats an adhesion sequence of Laminin protein. This restores the cutaneous structure and leaves a redensifying and restructuring effect on the skin.
Hexapeptide-2 is a synthetic peptide with sequence His-Trp-Ala-Trp-Phe-Lys, a competitor (antagonist) of endogenous α-MSH (peptide; alpha-Melanocyte-stimulating hormone) that promotes melanin pigment production and skin pigmentation.
Hexapeptide-3 is a synthetic biomimetic peptide (with the sequence: Ala-Asp-Leu-Lys-Pro-Thr) that mimics fibronectin found in skin extracellular matrix (ECM) and is involved in tissue repair, wound healing, and cell adhesion.
Hexapeptide-33 is a biologically active peptide that stimulates blood vessel formation, known under the trade name W3 peptide. It was developed by Novacell Technology (NCP901) using peptide library technology.
Hexapeptide-42 is a synthetic peptide with sequence Ile–Gln–Ala–Cys–Arg–Gly–NH2 that activates the Caspase-14, a proteolytic enzyme expressed only in the epidermis and responsible for Filaggrin metabolism.
Hexapeptide-48 HCl is a synthetic peptide, known under the trade name Rubixyl®, that acts as
Hexapeptide-9 is a synthetic peptide that repeats a part of collagen (sequence: Gly-Pro-Gln-Gly-Pro-Gln) that stimulates fibroblasts to boost collagen and hyaluronic acid production. It improves dermal firmness and elasticity while enhancing water retention of the skin.
Hexapeptide-94 Gamma Dipeptide-4 is a synthetic octapeptide with the sequence H-Arg-Leu-Arg-Trp-Arg-γ-Glu-Cys-Gly-OH. It is also known under the trade name Whitening peptide-1.
Active ingredient with boosting and moisturizing long-lasting effect, enhanced by its anti-free radical activity, thus preserving the youthfulness of lips.
InvisaSkin® Matrix Rebuilder-O is an anti-aging skin care complex combining the activity of Palmitoyl Hexapeptide-14 (former Palmitoyl Hexapeptide-6 with sequence N-Palmitoyl-L-phenylalanyl-L-alanyl-L-leucyl-L-leucyl-L-lysyl-L-leucinamide) and plant-derived glycoconjugates (Goji berry extract) fo
InvisaSkin®-64 Anti-Acne Treatment is a peptide-based complex a unique combination of hydrating delivery vehicle, anti-microbial peptide, and salicylic acid offers a gentle approach to treating the symptoms of acne.
Inyline™ Solution is a peptide-based complex with muscle-relaxing Botox-like action.
Pentapeptide-18 acts similar to natural enkephalins (proven in vitro study): it couples to the enkephalin receptor on the outside of the nerve cells, relaxing expression muscles and smoothing wrinkles.
MatriGold® is a complex containing a matrikine peptide Palmitoyl Pentapeptide-4 fused with colloidal gold particles. Palmitoyl Pentapeptide-4 is a superstar peptide known under the trade name Matrixyl™, and it was the first in matrikines range.
N-Prolyl Palmitoyl Tripeptide-56 Acetate is a new, innovative, and award-winning peptide that boosts collagen and fibronectin production, improving extracellular matrix structure, fibers organization, and skin density.
Naturally occurring peptides in the skin perform critical roles in skin maintenance and repair, and there is growing interest in harnessing these effects for therapeutic and cosmetic use.
Matrixyl™ synthe’6™ is a potent peptide that boosts six skin-rebuilding essentials: macromolecules - proteins and glycosaminoglycans.
A peptide-based wax, activates the protein and proteoglycan synthesis, which increases the density of the connective tissue and tangibly firms the lip‘s contours, moisturizes, restructures.
Highly efficient peptide combinations for the prevention of wrinkles and expression lines, thanks to an inhibiting effect on the contraction of the facial muscles.
Developed exclusively for MBR®, FibroBoost is based on a specific peptide complex, which has been modelled on the growth factors of the fibroblasts that are naturally present in our skin.
MelinOIL™ is an oil-soluble version of a-MSH (a-Melanocyte Stimulating Hormone) biomimetic peptide (Acetyl Hexapeptide-1) developed to promote the natural skin defense system against the sun and UV-induced damage, protecting cells and limiting premature photoaging.
Alpha-MSH a melanocyte-stimulating hormone, is one of the factors in the regulation of melanin production. It is involved in the control of tyrosinase activity, melanin synthesis, and melanosome transfer.
MVP Sapphire Lift is an advanced peptide-based complex that combats the loss of firmness with perfect synthetic gemstones.
Due to an ever-increasing demand for higher performance - more effective, faster action - we have seen the emergence of ingredients on the borderline with pharmaceuticals, with claims close to surgery.
Although hair disorders are not life-threatening, their profound impact on social interaction and on patients’ psychological aspects is undeniable. The demand for hair loss treatment has led to a multibillion-dollar industry.
Myristoyl Hexapeptide-16 is an eyelash booster lipo-peptide with sequence Myr-Leu-Lys-Lys-Ala-Leu-Lys that stimulates multiple genes responsible for keratin (hair protein) production. Keratin is the primary protein in hair, nails, and the outermost layer of the skin.
Myristoyl hexapeptide-23 is a synthetic lipo-peptide with antibacterial properties against Propionibacterium acnes (Cutibacterium acnes).
Myristoyl Hexapeptide-4 is a hydrophilic peptide rich in the essential amino acid threonine with sequence Myr-Thr-Lys-Thr-Thr-Lys-Ser-NH2, which is more bioactive, thanks to modifications during production.